The proposed program in research training and education is designed to prepare NRSA and non-NRSA postdoctoral trainees for careers in the emerging field of """"""""geroscience"""""""" ?the integrated, interdisciplinary study of aging and age-related diseases. The Buck Institute for Age Research is uniquely positioned to provide broad-based training and education in this field, and thereby ready its participants to make important contributions to our understanding of the biology of aging and its attendant health consequences. Some key assets of the Buck Institute in this regard are its strong institutional focus on aging research, highly interdisciplinary approach to research problems, advanced technologic infrastructure, outstanding faculty with diverse scientific and clinical expertise and prior teaching experience, and the unsurpassed regional research environment and facilities of the San Francisco Bay Area. The Buck Institute has devoted major effort and resources to the training of junior scientists, especially postdoctoral fellows, in aging research. In addition to working in the laboratories of Buck Institute faculty members, these fellows have access to didactic courses designed to better equip them for independent careers in aging research in academic or biotechnology settings, as well as practical instruction in career-development skills including research ethics, scientific presentations, grant writing and teaching. This postdoctoral training program's Specific Aims are to:
AIM 1. Provide postdoctoral trainees with interdisciplinary laboratory experience in geroscience ?the integrated study of aging and age-related diseases.
AIM 2. Provide postdoctoral trainees with didactic teaching in disciplines inherent to geroscience and practical instruction that will assist in their scientific career development.
|Brand, Martin D; Goncalves, Renata L S; Orr, Adam L et al. (2016) Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab 24:582-592|
|Goncalves, Renata L S; Quinlan, Casey L; Perevoshchikova, Irina V et al. (2015) Sites of superoxide and hydrogen peroxide production by muscle mitochondria assessed ex vivo under conditions mimicking rest and exercise. J Biol Chem 290:209-27|
|Orr, Adam L; Vargas, Leonardo; Turk, Carolina N et al. (2015) Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol 11:834-6|
|Quinlan, Casey L; Goncalves, Renata L S; Hey-Mogensen, Martin et al. (2014) The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem 289:8312-25|
|Goncalves, Renata L S; Rothschild, Daniel E; Quinlan, Casey L et al. (2014) Sources of superoxide/H2O2 during mitochondrial proline oxidation. Redox Biol 2:901-9|
|Orr, Adam L; Ashok, Deepthi; Sarantos, Melissa R et al. (2014) Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase. PLoS One 9:e89938|
|Quinlan, Casey L; Perevoschikova, Irina V; Goncalves, Renata L S et al. (2013) The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production. Methods Enzymol 526:189-217|
|Quinlan, Casey L; Perevoshchikova, Irina V; Hey-Mogensen, Martin et al. (2013) Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol 1:304-12|
|Brand, M D; Orr, A L; Perevoshchikova, I V et al. (2013) The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol 169 Suppl 2:1-8|
|Orr, Adam L; Ashok, Deepthi; Sarantos, Melissa R et al. (2013) Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free Radic Biol Med 65:1047-59|
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