The University of California, Davis (UC Davis) is requesting continued support for the Clinical and Translational Science Center (CTSC). Since its initiation, the UC Davis CTSC has been firmly established as a major local, regional, and national leader in transforming the clinical and translational research enterprise and has received enthusiastic support from throughout UC Davis. The CTSC has created an extensive community of partners, ranging from the UC Davis Health System, colleges and schools to local community partners, regional partners including the University of Nevada and national partners, and other CTSA sites The CTSC has fostered a cadre of successful trainees that are well prepared for a career trajectory in clinical and translational research, built an extensive infrastructure to support trainees, investigators, and community partners, and emerged as a major contributor to national CTSA goals. At the end of the initial funding period, the UC Davis CTSC is an organization that is: (1) responsive and familiar to investigators;(2) flexible;(3) versatile;(4) well-linked to university leadership, to participating academic units, and to the community;and (5) actively reducing barriers and facilitating translation of research gains into medical practice. The key features of our program are: education programs focused on """"""""team science"""""""";flexible infrastructure;extensive collaborations across UC Davis;and engagement of local, regional, and national partners. The CTSC has played major leadership roles in establishing the national CTSA Consortium, and has been a leader or collaborator on 15 CTSA supplemental awards. In the next grant period, the CTSC will focus on 3 goals firmly anchored in our institutional fabric, the community, and the CTSA Consortium: (1) Completion of a comprehensive service and resource toolset for the research community;(2) Education and training of a well prepared workforce of trainees, staff, and investigators;and (3) Ensuring translational research is advanced to improve human health across the lifespan. To realize these goals, the CTSC will remain under the continued leadership of Lars Berglund, MD, PhD, supported by a cadre of directors and associate directors overseeing individual CTSC programs, and guided by a comprehensive committee structure designed to firmly anchor the CTSC with institutional leadership, faculty, trainees, the community, and the national CTSA Consortium.

Public Health Relevance

The UC Davis CTSC has established a strong training and infrastructure resource to support and promote health research. Through the CTSC, research findings relevant to health and disease are made available to health professionals and community members. In addition, the UC Davis CTSC is part of a national network to ensure a broad-based information exchange between scientists, health professionals, and community members.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Linked Training Award (TL1)
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Special Emphasis Panel (ZRR1-CR-1 (01))
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Sawczuk, Andrea
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University of California Davis
Internal Medicine/Medicine
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United States
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Wang, Shuyun; Mundada, Lakshmi; Johnson, Sean et al. (2015) Characterization and angiogenic potential of human neonatal and infant thymus mesenchymal stromal cells. Stem Cells Transl Med 4:339-50
Hodonsky, Chani; Mundada, Lakshmi; Wang, Shuyun et al. (2015) Effects of scaffold material used in cardiovascular surgery on mesenchymal stem cells and cardiac progenitor cells. Ann Thorac Surg 99:605-11
Polage, Christopher R; Gyorke, Clare E; Kennedy, Michael A et al. (2015) Overdiagnosis of Clostridium difficile Infection in the Molecular Test Era. JAMA Intern Med 175:1792-801
Luo, Zhen; Loja, Melissa N; Farwell, D Greg et al. (2014) Widefield optical imaging of changes in uptake of glucose and tissue extracellular pH in head and neck cancer. Cancer Prev Res (Phila) 7:1035-44
Roegner, Amber F; Puschner, Birgit (2014) Aggregate culture: A more accurate predictor of microcystin toxicity for risk assessment. Toxicon 83:1-14
McDonnel, S J; Tell, L A; Murphy, B G (2014) Pharmacokinetics and pharmacodynamics of suberoylanilide hydroxamic acid in cats. J Vet Pharmacol Ther 37:196-200
Kost, Rhonda G; Lee, Laura N; Yessis, Jennifer L et al. (2014) Research participant-centered outcomes at NIH-supported clinical research centers. Clin Transl Sci 7:430-40
Murphy, B; Hillman, C; McDonnel, S (2014) Peripheral immunophenotype and viral promoter variants during the asymptomatic phase of feline immunodeficiency virus infection. Virus Res 179:34-43
Loja, Melissa N; Luo, Zhen; Greg Farwell, D et al. (2013) Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer. Int J Cancer 132:1613-23
McDonnel, Samantha J; Sparger, Ellen E; Luciw, Paul A et al. (2012) Pharmacologic reactivation of latent feline immunodeficiency virus ex vivo in peripheral CD4+ T-lymphocytes. Virus Res 170:174-9

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