This revised application for a Clinical and Translational Science Award (CTSA) would support the continued development of the Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision Is to improve health of the diverse and underserved population of urban Los Angeles and. In doing so, to gain knowledge that we can share with others to Improve health In urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: build on many independent strengths to create an integrated academic home that places high priority on clinical and translational science;create new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorities of our local communities;transform education and training to create a cadre of people with a major career focus on clinical and translational research;and implement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: outstanding resources for active development of new research projects and teams, a robust infrastructure to promote and support basic, clinical and community research, cutting edge methodologies for data acquisition, integration, management and analysis;integrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities;a novel approach to dissemination of our findings using professional communications expertise;and a professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translational research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR000132-04
Application #
8490528
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Boller, Francois
Project Start
2010-07-01
Project End
2015-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
4
Fiscal Year
2013
Total Cost
$166,103
Indirect Cost
$8,714
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Nicol, Alcina F; Brunette, Laurie L; Nuovo, Gerard J et al. (2016) Secretory Leukocyte Protease Inhibitor Expression and High-Risk HPV Infection in Anal Lesions of HIV-Positive Patients. J Acquir Immune Defic Syndr 73:27-33
Jang, Julie K; Khawli, Leslie A; Canter, David C et al. (2016) Systemic delivery of chTNT-3/CpG immunoconjugates for immunotherapy in murine solid tumor models. Cancer Immunol Immunother 65:511-23
Angell, Amber M; Frank, Gelya; Solomon, Olga (2016) Latino Families' Experiences With Autism Services: Disparities, Capabilities, and Occupational Justice. OTJR (Thorofare N J) :
Skeate, Joseph G; Porras, Tania B; Woodham, Andrew W et al. (2016) Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection. J Gen Virol 97:422-34
Agnello, Melissa; Finkel, Steven E; Wong-Beringer, Annie (2016) Fitness Cost of Fluoroquinolone Resistance in Clinical Isolates of Pseudomonas aeruginosa Differs by Type III Secretion Genotype. Front Microbiol 7:1591
Pulido, Mario A; DerHartunian, Meleeneh Kazarian; Sehgal, Prerna et al. (2016) Data on isoaspartylation of neuronal ELAVL proteins. Data Brief 9:1052-1055
Russell, Christopher J; Shiroishi, Mark S; Siantz, Elizabeth et al. (2016) The use of inhaled antibiotic therapy in the treatment of ventilator-associated pneumonia and tracheobronchitis: a systematic review. BMC Pulm Med 16:40
Woodham, Andrew W; Yan, Lisa; Skeate, Joseph G et al. (2016) T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation. Papillomavirus Res 2:21-30
Pulido, Mario A; DerHartunian, Meleeneh Kazarian; Qin, Zhenxia et al. (2016) Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4. J Neuroimmunol 299:70-78
Yan, Lisa; Da Silva, Diane M; Verma, Bhavna et al. (2015) Forced LIGHT expression in prostate tumors overcomes Treg mediated immunosuppression and synergizes with a prostate tumor therapeutic vaccine by recruiting effector T lymphocytes. Prostate 75:280-91

Showing the most recent 10 out of 28 publications