During the past cycle, following consultation with our internal and external advisory boards, organizational governance structure and the leadership of NCRR, we have focused our efforts on two overarching themes - Translational Therapeutics and Bridging the Pediatric to Adult Divide, taking advantage of resources particular to our institutions. We have fostered interdisciplinary and translational research by a series of """"""""top down"""""""" and """"""""bottom up"""""""" funding initiatives. CTSA support and institutional investment aided by ARRA funding has increased dramatically the footprint of ITMAT more than 7 fold to -150,000 nsf comprising an expanded, integrated and re-purposed Clinical and Translational Research Center (CTRC) that succeeds the Penn and CHOP GCRCs, dry and wet bench laboratory space, a series of cores and a new home for ITMAT educational programs. ITMAT also supports seminars, workshops and an annual international meeting highlighting the opportunities that the CTSA affords on our campus to pursue clinical and translational research. Interdisciplinary research has increased dramatically on, between, and within the partner institutions during the past funding cycle and these trends have been most pronounced amongst members of ITMAT During the coming cycle we envisage the continued growth and development of our educational programs; the continued expansion - via recruitment and education - ofthe critical mass of investigators pursuant of clinical and translational research;enhancement and expansion of our core infrastructure and the development and expansion of programs focused on our two overarching themes. In particular we hope to impact patient care in the community by projecting our two strategic goals to alter the current paradigm of comparative effectiveness research by integrating expertise in basic, pediathc and adult pharmacology and to contribute to predictive strategies in the personalization of medicine.

Public Health Relevance

PENN, CHOP, Monell, Wistar Institute, and the University ofthe Sciences of Philadelphia have benefited greatly from the first cycle of funding ofthe CTSA, which allowed the development of new centers, research programs, cores and a robust educational program which involve more than 800 investigators across campus and from partner institutions, as well as adding to consortial activities nationally.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Training Award (TL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Boller, Francois
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Schools of Medicine
United States
Zip Code
Pardes, A M; Freedman, B R; Fryhofer, G W et al. (2016) Males have Inferior Achilles Tendon Material Properties Compared to Females in a Rodent Model. Ann Biomed Eng 44:2901-10
Singh, Pritam; Aggarwal, Rajesh; Pucher, Philip H et al. (2015) An immersive ""simulation week"" enhances clinical performance of incoming surgical interns improved performance persists at 6 months follow-up. Surgery 157:432-43
Quatromoni, Jon G; Singhal, Sunil; Bhojnagarwala, Pratik et al. (2015) An optimized disaggregation method for human lung tumors that preserves the phenotype and function of the immune cells. J Leukoc Biol 97:201-9
Xu, Melody J; Cooke, Mariana; Steinmetz, David et al. (2015) A novel approach for the detection and genetic analysis of live melanoma circulating tumor cells. PLoS One 10:e0123376
Hashimoto, Daniel A; Sirimanna, Pramudith; Gomez, Ernest D et al. (2015) Deliberate practice enhances quality of laparoscopic surgical performance in a randomized controlled trial: from arrested development to expert performance. Surg Endosc 29:3154-62
Miyasaka, Kiyoyuki W; Buchholz, Joseph; LaMarra, Denise et al. (2015) Development and implementation of a clinical pathway approach to simulation-based training for foregut surgery. J Surg Educ 72:625-35
Hashimoto, Daniel A; Gomez, Ernest D; Beyer-Berjot, Laura et al. (2015) A Randomized Controlled Trial to Assess the Effects of Competition on the Development of Laparoscopic Surgical Skills. J Surg Educ 72:1077-84
Wise, Megan C; Hutnick, Natalie A; Pollara, Justin et al. (2015) An Enhanced Synthetic Multiclade DNA Prime Induces Improved Cross-Clade-Reactive Functional Antibodies when Combined with an Adjuvanted Protein Boost in Nonhuman Primates. J Virol 89:9154-66
Singh, Pritam; Aggarwal, Rajesh; Hashimoto, Daniel A et al. (2014) A comparative study of contrasting surgical residency programs. World J Surg 38:2495-501
Quatromoni, Jon G; Predina, Jarrod D; Bhojnagarwala, Pratik et al. (2014) Adenoviral-based immunotherapy provides local disease control in an orthotopic murine model of esophageal cancer. J Immunother 37:283-92

Showing the most recent 10 out of 15 publications