During the past cycle, following consultation with our internal and external advisory boards, organizational governance structure and the leadership of NCRR, we have focused our efforts on two overarching themes - Translational Therapeutics and Bridging the Pediatric to Adult Divide, taking advantage of resources particular to our institutions. We have fostered interdisciplinary and translational research by a series of """"""""top down"""""""" and """"""""bottom up"""""""" funding initiatives. CTSA support and institutional investment aided by ARRA funding has increased dramatically the footprint of ITMAT more than 7 fold to -150,000 nsf comprising an expanded, integrated and re-purposed Clinical and Translational Research Center (CTRC) that succeeds the Penn and CHOP GCRCs, dry and wet bench laboratory space, a series of cores and a new home for ITMAT educational programs. ITMAT also supports seminars, workshops and an annual international meeting highlighting the opportunities that the CTSA affords on our campus to pursue clinical and translational research. Interdisciplinary research has increased dramatically on, between, and within the partner institutions during the past funding cycle and these trends have been most pronounced amongst members of ITMAT During the coming cycle we envisage the continued growth and development of our educational programs; the continued expansion - via recruitment and education - ofthe critical mass of investigators pursuant of clinical and translational research;enhancement and expansion of our core infrastructure and the development and expansion of programs focused on our two overarching themes. In particular we hope to impact patient care in the community by projecting our two strategic goals to alter the current paradigm of comparative effectiveness research by integrating expertise in basic, pediathc and adult pharmacology and to contribute to predictive strategies in the personalization of medicine.
PENN, CHOP, Monell, Wistar Institute, and the University ofthe Sciences of Philadelphia have benefited greatly from the first cycle of funding ofthe CTSA, which allowed the development of new centers, research programs, cores and a robust educational program which involve more than 800 investigators across campus and from partner institutions, as well as adding to consortial activities nationally.
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|Hu, Ray; Morley, Michael P; Brandimarto, Jeffrey et al. (2018) Genetic Reduction in Left Ventricular Protein Kinase C-? and Adverse Ventricular Remodeling in Human Subjects. Circ Genom Precis Med 11:e001901|
|Marek, Andrew J; Chu, Emily Y; Ming, Michael E et al. (2018) Impact of a smartphone application on skin self-examination rates in patients who are new to total body photography: A randomized controlled trial. J Am Acad Dermatol 79:564-567|
|Brynildsen, Julia K; Lee, Bridgin G; Perron, Isaac J et al. (2018) Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal. Proc Natl Acad Sci U S A 115:4282-4287|
|Leonard, Charles E; Brensinger, Colleen M; Bilker, Warren B et al. (2017) Gastrointestinal bleeding and intracranial hemorrhage in concomitant users of warfarin and antihyperlipidemics. Int J Cardiol 228:761-770|
|Jain, P; Fierst, T M; Han, H J et al. (2017) CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles. Oncogene 36:6348-6358|
|Freedman, Benjamin R; Fryhofer, George W; Salka, Nabeel S et al. (2017) Mechanical, histological, and functional properties remain inferior in conservatively treated Achilles tendons in rodents: Long term evaluation. J Biomech 56:55-60|
|Marek, Andrew J; Ming, Michael E; Bartlett, Edmund K et al. (2016) Acral Lentiginous Histologic Subtype and Sentinel Lymph Node Positivity in Thin Melanoma. JAMA Dermatol 152:836-7|
|Carlin, Jesse L; McKee, Sarah E; Hill-Smith, Tiffany et al. (2016) Removal of high-fat diet after chronic exposure drives binge behavior and dopaminergic dysregulation in female mice. Neuroscience 326:170-179|
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