The Yale Center for Clinical Investigation (YCCI) was created to provide a home for training the next generation of clinical investigators. Key programmatic goals are to 1) attract highly talented students and junior faculty across medicine, nursing, public health, biological sciences and biomedical engineering; and train them in the use of state-of-the-art research tools; give them the skills to work within complex research teams; and support their professional development; and 2) foster the translation of disease-related discoveries from the laboratory into the clinic and then the community by: stimulating the creation of interdisciplinary teams; making available state-of-the-art core facilities and expanded biostatistical and bioinformatics resources; establishing organizational and regulatory infrastructure for clinical studies; and forging new partnerships that will integrate community leaders, physicians, and health centers and encourage participation in research. Participating institutions include the Schools of Medicine, Nursing, and Public Health, the department of Biomedical Engineering and the Graduate Programs in Biological and Biomedical Sciences. The Junior Faculty Scholars award program and the Investigative Medicine program (IMP) are central to YCCI's education and training efforts. IMP is a unique doctoral program that offers Ph.D. degrees in Health Sciences Research to highly qualified M.D. fellows embarking on careers in translational or clinical research and the junior faculty scholars program is a career development program. YCCI has also created a Society of Mentors who participate actively in the training and nurturing of the YCCI Scholars. Pilot and feasibility (P&F) grants will be awarded for: 1) interdisciplinary translational team research; 2) development of novel methodologies; 3) Use of Core (ind imaging) technologies; and 4) community-based research. YCCI will cluster research cores around common themes, including: imaging; genomics and proteomics; cell and tissue based tech; Integrated metabolics; cognition and biobehavior; and animal models. The Office of Research Services will provide robust facilities and resources for regulatory, biostatistical, bioinformatics, recruitment and other support services. YCCI will have an office to coordinate the University's efforts to address health issues facing our community and our national community.

Public Health Relevance

This research has direct relevance to public health in that its goals are to facilitate clinical research, including by training the next generation of clinical researchers, that will lead to better treatments for human disease and better health outcomes.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR000141-10
Application #
8925172
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Merchant, Carol
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
10
Fiscal Year
2015
Total Cost
$307,994
Indirect Cost
$22,814
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06510
Burt, Joshua B; Demirta?, Murat; Eckner, William J et al. (2018) Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography. Nat Neurosci 21:1251-1259
Letzen, Brian; Park, Jiheum; Tuzun, Zeynep et al. (2018) Design and Development of a Miniaturized Percutaneously Deployable Wireless Left Ventricular Assist Device: Early Prototypes and Feasibility Testing. ASAIO J 64:147-153
Quao, Zola Chihombori; Tong, Mancy; Bryce, Elena et al. (2018) Low molecular weight heparin and aspirin exacerbate human endometrial endothelial cell responses to antiphospholipid antibodies. Am J Reprod Immunol 79:
Sreekrishnan, Anirudh; Leasure, Audrey C; Shi, Fu-Dong et al. (2017) Functional Improvement Among Intracerebral Hemorrhage (ICH) Survivors up to 12 Months Post-injury. Neurocrit Care 27:326-333
Ford, Kristin J; Joop, Allen; Memon, Raima A et al. (2017) Pedestrian safety in patients with Parkinson's disease: A case-control study. Mov Disord 32:1748-1755
Birchall, Elizabeth L; Walker, Harrison C; Cutter, Gary et al. (2017) The effect of unilateral subthalamic nucleus deep brain stimulation on depression in Parkinson's disease. Brain Stimul 10:651-656
Murray, John D; Anticevic, Alan (2017) Toward understanding thalamocortical dysfunction in schizophrenia through computational models of neural circuit dynamics. Schizophr Res 180:70-77
Hajek, Michael; Sewell, Andrew; Kaech, Susan et al. (2017) TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. Cancer 123:1778-1790
Martenson, James S; Yamasaki, Tokiwa; Chaudhury, Nashid H et al. (2017) Assembly rules for GABAA receptor complexes in the brain. Elife 6:
Foss-Feig, Jennifer H; Adkinson, Brendan D; Ji, Jie Lisa et al. (2017) Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biol Psychiatry 81:848-861

Showing the most recent 10 out of 27 publications