The Institute of Translational Health Sciences (ITHS) is a collaboration between 3 partners;the University of Washington, the Fred Hutchinson Cancer Research Center, and Seattle Children's. Over the last 4 years, the work of the ITHS has also extended to partner institutions in the Puget Sound and throughout the 5-state region of Washington, Wyoming, Alaska, Montana, and Idaho. In 2007, we established the ITHS as a "collaboratory"- an academic home without walls for translational investigators in our region. The ITHS supports novel research resources in biomedical informatics, biostatistics, therapeutic product development and clinical research, supported by expertise in bioethics and regulatory practices. To train the next generation of researchers, the ITHS has developed multidisciplinary educational offerings in translational research: structured training programs (pre-doctoral and post-doctoral programs) and lifelong learning programs (flexible continuing education for researchers at any stage of their career). The ITHS has also established collaboration networks for research and engaged nearly 2000 members and users. ITHS memberships and networks have spanned across the 5-state region and diverse populations such as the Alaska Native/ American Indian communities to engage new groups in clinical and translational research. In the proposed funding period we will extend the collaboratory to multidisciplinary teams and focus on moving discoveries across the translational research continuum rapidly and efficiently. We will develop state-of-the-art methods and tools to transform research processes. Our overarching goals are to: 1) Develop and promote multidisciplinary teams and academic-community partnerships to increase the speed and quality of translational research, 2) Train scientists to cross the interface of translational research phases, so their ideas will move more quickly to a health impact, and 3) Transform research processes and practices in our regions and the CTSA network through dissemination of innovative approaches and best practices.

Public Health Relevance

The health care needs of our nation are complex and finding effective solutions and cures will require a multi- disciplinary, multi-faceted approach based on innovation and state-of-the-art science. The CTSA program, both at the local level and through the national CTSA consortium, provides the elements needed to accelerate discoveries at the bench into tangible health benefits for our communities.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR000422-07
Application #
8499458
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Wilson, Todd
Project Start
2007-09-17
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
7
Fiscal Year
2013
Total Cost
$545,630
Indirect Cost
$32,438
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Yeung, Kai; Basu, Anirban; Hansen, Ryan N et al. (2016) Impact of a Value-based Formulary on Medication Utilization, Health Services Utilization, and Expenditures. Med Care :
Yin, Jia; Wang, Joanne (2016) Renal drug transporters and their significance in drug-drug interactions. Acta Pharm Sin B 6:363-373
Dang, Uyen T; Zamora, Idalia; Hevener, Kirk E et al. (2016) Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden. Antimicrob Agents Chemother 60:5604-7
Bowlby, Wilson; Zelnick, Leila R; Henry, Connor et al. (2016) Physical activity and metabolic health in chronic kidney disease: a cross-sectional study. BMC Nephrol 17:187
Patilea-Vrana, G; Unadkat, J D (2016) Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model. Clin Pharmacol Ther 100:413-418
Kent, Travis; Arnold, Samuel L; Fasnacht, Rachael et al. (2016) ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes. Biol Reprod 94:12
Yamaura, Yoshiyuki; Chapron, Brian D; Wang, Zhican et al. (2016) Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism. Drug Metab Dispos 44:329-35
Tran, Len N; Back, Anthony L; Creutzfeldt, Claire J (2016) Palliative Care Consultations in the Neuro-ICU: A Qualitative Study. Neurocrit Care 25:266-72
Jones, Jesse A; Virga, Kristopher G; Gumina, Giuseppe et al. (2016) Recent Advances in the Rational Design and Optimization of Antibacterial Agents. Medchemcomm 7:1694-1715
Yin, Jia; Duan, Haichuan; Wang, Joanne (2016) Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation. J Pharmacol Exp Ther 359:401-410

Showing the most recent 10 out of 106 publications