In just over four years, the Weill Cornell Medical Center Clinical and Translational Science Center (CTSC) has established a strong and highly effective clinical and translational science infrastructure spanning six diverse partners, each a center of excellence: Memorial Sloan-Kettering Cancer Center;Hospital for Special Surgery;Hunter College School of Nursing, Hunter College Gene Center-a Research Center for Minority Institutions (RCMI);Cornell University Cooperative Extension;and Cornell University, Ithaca. The mission of the CTSC in continuation is to leverage the resources and expertise of this rich multi-institutional partnership to.create new interdisciplinary teams and support cutting-edge research from bench to bedside to community to health care practice. The proposed grant adds a new partner, the Animal Medical Center a few blocks from WCMC, to increase collaboration with Cornell University College of Veterinary Medicine. Jointly, they bring a new dimension to our CTSC research and their expertise in small animals will enhance pre-clinical research in the area of drug discovery and device development. Built on the accomplishments achieved during the initial funding period, the strategic plans for the next five years are geared to rapidly advance translational science discoveries by: 1) Enhancing the Drug Discovery Pipeline;2) Increasing the Breadth of Research Resources;3) Adding New Expertise and Training Programs;and 4) Enhancing Community Engagement and Dissemination. Moving forward, the anticipated benefits of fostering "Innovation through Collaboration" during the next funding period include: 1) Further generation of novel ideas leading to drug development and medical devices which benefit patient care;2) Increased collaborative efforts with partners and industry, to facilitate research to improve the general health of the public;3) Enhanced clinical translational (C/T) educational programs in comparative effectiveness research, global health and health information technology;4) Enhanced community engagement;5) Increased centralization of C/T research, education, infrastructure, and databases;and 6) Enhanced evaluation and tracking of CTSC programs.

Public Health Relevance

The broad research support infrastructure of the CTSC and its programs to foster interactions among basic scientists, clinicians and community practitioners are key to the rapid translation of basic science discoveries into effective clinical practice. Our CTSC is distinct in the heterogeneity of its component institutions, providing unparalleled opportunities for collaboration and training in all areas of biomedical sciences.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR000459-07
Application #
8499480
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Sufian, Meryl
Project Start
2007-09-17
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
7
Fiscal Year
2013
Total Cost
$118,158
Indirect Cost
$8,752
Name
Weill Medical College of Cornell University
Department
None
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Montrose, David C; Zhou, Xi Kathy; McNally, Erin M et al. (2016) Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden. Cancer Prev Res (Phila) 9:721-31
Ye, Haobin; Adane, Biniam; Khan, Nabilah et al. (2016) Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche. Cell Stem Cell 19:23-37
McCorry, Mary Clare; Puetzer, Jennifer L; Bonassar, Lawrence J (2016) Characterization of mesenchymal stem cells and fibrochondrocytes in three-dimensional co-culture: analysis of cell shape, matrix production, and mechanical performance. Stem Cell Res Ther 7:39
Carney, Brandon; Carlucci, Giuseppe; Salinas, Beatriz et al. (2016) Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models. Mol Imaging Biol 18:386-92
Jia, Zhenshan; Zhang, Yijia; Chen, Yen Hsun et al. (2015) Simvastatin prodrug micelles target fracture and improve healing. J Control Release 200:23-34
Gupta, Ajay; Kesavabhotla, Kartik; Baradaran, Hediyeh et al. (2015) Plaque echolucency and stroke risk in asymptomatic carotid stenosis: a systematic review and meta-analysis. Stroke 46:91-7
Novakofski, K D; Berg, L C; Bronzini, I et al. (2015) Joint-dependent response to impact and implications for post-traumatic osteoarthritis. Osteoarthritis Cartilage 23:1130-7
Carlucci, Giuseppe; Carney, Brandon; Brand, Christian et al. (2015) Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma. Mol Imaging Biol 17:848-55
Karuppagounder, Saravanan S; Kumar, Amit; Shao, Diana S et al. (2015) Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases. Brain Res 1628:273-87
Yellen, Paige; Foster, David A (2014) Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells. Cancer Lett 353:258-63

Showing the most recent 10 out of 23 publications