Abstract

The Scripps Translational Science Institute (STSI) aims to support and catalyze impactful translational and clinical research fornot only the Scripps institutions, consisting of The Scripps Research Institute and Scripps Health, but also an extensive collaborating investigative network that extends from the La Jolla Mesa throughout the United States.The Scripps program combines the largest independent biomedical institute in the country with the dominant health care system in San Diego, along with an extensive partnership with the San Diego Supercomputer Center, one of the 4 national resource centers of its l

Public Health Relevance

Medicine as practiced today consists of mass screening and the use of the same medications for all patients with a particular diagnosis. Our newfound ability to define the medical essence of each individual paves the way for a more efficient, safer, and less expensive form of healthcare in the future. By bringing together an exceptionally talented and productive research community, STSI will catapult this new form of medicine.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Training Award (TL1)
Project #
5TL1TR001113-02
Application #
8743356
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Talbot, Bernard
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
$197,340
Indirect Cost
$13,284

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Smith, Alyson S; Nowak, Roberta B; Zhou, Sitong et al. (2018) Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability. Proc Natl Acad Sci U S A 115:E4377-E4385
Spierling, Samantha R; Kreisler, Alison D; Williams, Casey A et al. (2018) Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability. Physiol Behav 192:3-16
Tat, John; Loriot, Céline; Henze, Martha et al. (2017) CKS protein overexpression renders tumors susceptible to a chemotherapeutic strategy that protects normal tissues. Oncotarget 8:114911-114923
Neumann, Sylvia; Chassefeyre, Romain; Campbell, George E et al. (2017) KymoAnalyzer: a software tool for the quantitative analysis of intracellular transport in neurons. Traffic 18:71-88
LaMere, Sarah A; Thompson, Ryan C; Meng, Xiangzhi et al. (2017) H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3. J Immunol 199:3158-3175
Jacob, Nicholas T; Lockner, Jonathan W; Schlosburg, Joel E et al. (2016) Investigations of Enantiopure Nicotine Haptens Using an Adjuvanting Carrier in Anti-Nicotine Vaccine Development. J Med Chem 59:2523-9
Zhou, Bin; Eubanks, Lisa M; Jacob, Nicholas T et al. (2016) Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose. Bioorg Med Chem Lett 26:5078-5081
Truong, Linh; Tat, John; Booy, Molly et al. (2016) The Asian Grocery Store-Based Cancer Education Program: Creating New Education Modules. J Cancer Educ 31:292-300
Mirendil, H; Thomas, E A; De Loera, C et al. (2015) LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage. Transl Psychiatry 5:e541
Komori, H Kiyomi; Hart, Traver; LaMere, Sarah A et al. (2015) Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation. J Immunol 194:1565-79

Showing the most recent 10 out of 12 publications