San Antonio, the gateway to South Texas, is the 7^ largest city in the US and the largest metropolitan area with a majority Hispanic population (63%). South Texas is about the size of Ohio, and comprises an impoverished and largely Hispanic population with disproportionate rates of diabetes and obesity, exacerbated by a lack of health insurance and poor access to health care. This region also contains numerous US military installations, and active-duty service members and veterans often have special health issues, including increased risk for post-traumatic stress disorder and traumatic injuries. Unfortunately, neither better access to care nor improved care delivery can eliminate health disparities and meet these complex needs. In addition, research across the full T l to T4 translational spectrum is required to eliminate knowledge gaps and establish real-wortd effectiveness that improves health care for our populations. In 2006, UTHSCSA established the Institute for Integration of Medicine and Science (IIMS) to improve health and reduce disparities by accelerating scientific discoveries and applications across the full translational research spectrum. For example, IIMS expanded the number of clinical research units that extend to the Texas-Mexico border from 1 to 7, and dramatically increasing participant access to clinical and translational science. We increased, from 2 to 6, the Practice-Based Research Networks that focus on diverse ambulatory populations. Efforts to address translational science workforce needs over the past 5-10 years have graduated 100 Masters Clinical Investigation students, supported 19 successful KL2 Scholars, and established new joint Translational Science PhD and Certificate programs. In this proposal, we provide strategies to spur clinical and translational science evolution, catalyze research teams, and implement programs that produce creative, collaborative, and culturally diverse scientists.
Our Specific Aims will: 1. Accelerate clinical and translational research innovation and effective team science along the entire 11 to T4 research spectrum by providing an academic home integrated with our strategic partner institutions. Expand, diversify, and enhance the workforce of interdisciplinary translational biomedical scientists. Implement effective methods to continuously evaluate and optimize services, increase efficiencies, improve processes, and reduce costs across all IIMS programs.

Public Health Relevance

Based on our vision of improving the health status of South Texas by accelerating scientific discoveries and public health applications, we will deploy strategic resources that focus on prevalent challenges in our region, including: 1) the health needs of our underserved Hispanic population, 2) the special health issues facing active-duty military and veteran populations, and 3) limitations in the translational science workforce required to fill in critical knowledge gaps and improve health in South Texas and the US.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Training Award (TL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Sawczuk, Andrea
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center San Antonio
Internal Medicine/Medicine
Schools of Medicine
San Antonio
United States
Zip Code
Ishaque, Mariam; Manning, Janessa H; Woolsey, Mary D et al. (2016) Lenticulostriate arterial distribution pathology may underlie pediatric anoxic brain injury in drowning. Neuroimage Clin 11:167-72
Li, Wei; Long, Justin Alexander; Watts, Lora et al. (2016) Spatiotemporal changes in diffusion, T2 and susceptibility of white matter following mild traumatic brain injury. NMR Biomed 29:896-903
Fucich, Elizabeth A; Paredes, Denisse; Morilak, David A (2016) Therapeutic Effects of Extinction Learning as a Model of Exposure Therapy in Rats. Neuropsychopharmacology 41:3092-3102
Talley Watts, Lora; Long, Justin Alexander; Boggs, Robert Cole et al. (2016) Delayed Methylene Blue Improves Lesion Volume, Multi-Parametric Quantitative Magnetic Resonance Imaging Measurements, and Behavioral Outcome after Traumatic Brain Injury. J Neurotrauma 33:194-202
Dao, Vinh; Liu, Yang; Pandeswara, Srilakshmi et al. (2016) Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells. Cancer Res 76:5970-5982
Klein, David A; Adelman, William P; Thompson, Amy M et al. (2015) All Military Adolescents Are Not the Same: Sexuality and Substance Use among Adolescents in the U.S. Military Healthcare System. PLoS One 10:e0141430
Reveles, Kelly R; Mortensen, Eric M; Attridge, Russell T et al. (2015) Comparative-effectiveness of vancomycin and linezolid as part of guideline-recommended empiric therapy for healthcare-associated pneumonia. BMC Res Notes 8:450
Long, Justin A; Watts, Lora T; Li, Wei et al. (2015) The effects of perturbed cerebral blood flow and cerebrovascular reactivity on structural MRI and behavioral readouts in mild traumatic brain injury. J Cereb Blood Flow Metab 35:1852-61
González-Juarbe, Norberto; Mares, Chris A; Hinojosa, Cecilia A et al. (2015) Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia. Infect Immun 83:614-24
Acheson, Ashley; Tagamets, Malle A; Winkler, Anderson et al. (2015) Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance-use disorders performing a go/no-go task. Brain Behav 5:e00352

Showing the most recent 10 out of 32 publications