During the past three years, members of the Facial Imaging Core have worked with the Consortium to apply novel methods to more effectively diagnose FAS using 3D images from an ethnically diverse sample. These data and their subsequent analyses were used to identify features which consistently and reliably distinguished individuals with a clinical diagnosis of FAS from controls. Based on the initial success of the 'Facial Imaging Core', we now propose an expanded series of aims to be part of a clinical project named '3D Facial Imaging in FASD'. Subsequent work proposed in this study will build on the lessons learned in this first phase of research and utilize improved technology and sampling procedures to extend the diagnostic utility of these novel techniques to a wider range of individuals with prenatal alcohol exposure or FASD. In collaboration with several clinical projects, we will collect a longitudinal, multi-ethnic sample of individuals prenatally exposed to alcohol. This sample will allow us to reliably separate the effects of ethnic variation and developmental age from those due to alcohol exposure. We will also continue to work with the basic science projects to ensure that results in the different species (human, mouse, sheep) are used to inform analyses in each project. The overarching goals of this project are to: Goal 1: improve understanding of the dysmorphic features in FAS and FASD;Goal 2: enhance the capability for definitive diagnosis of FAS and the broader spectrum of FASD at different stages of the lifespan;and Goal 3: establish whether there is a relationship between FAS and FASD dysmorphic features and the specific underlying impairments in brain function.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AA014809-08
Application #
8127952
Study Section
Special Emphasis Panel (ZAA1-CC (11))
Program Officer
Dunty, Jr, William
Project Start
2003-09-30
Project End
2012-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
8
Fiscal Year
2011
Total Cost
$239,727
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Genetics
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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Jacobson, Sandra W; Jacobson, Joseph L; Molteno, Christopher D et al. (2017) Heavy Prenatal Alcohol Exposure is Related to Smaller Corpus Callosum in Newborn MRI Scans. Alcohol Clin Exp Res 41:965-975
Suttie, Michael; Wetherill, Leah; Jacobson, Sandra W et al. (2017) Facial Curvature Detects and Explicates Ethnic Differences in Effects of Prenatal Alcohol Exposure. Alcohol Clin Exp Res 41:1471-1483
Ibrahim, Amel; Suttie, Michael; Bulstrode, Neil W et al. (2016) Combined soft and skeletal tissue modelling of normal and dysmorphic midface postnatal development. J Craniomaxillofac Surg 44:1777-1785
Carter, R Colin; Jacobson, Joseph L; Molteno, Christopher D et al. (2016) Fetal Alcohol Growth Restriction and Cognitive Impairment. Pediatrics 138:
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McCarthy, Neil; Wetherill, Leah; Lovely, C Ben et al. (2013) Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development 140:3254-65
Suttie, Michael; Foroud, Tatiana; Wetherill, Leah et al. (2013) Facial dysmorphism across the fetal alcohol spectrum. Pediatrics 131:e779-88
Swaminathan, Shanker; Shen, Li; Risacher, Shannon L et al. (2012) Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Brain Imaging Behav 6:1-15
Foroud, Tatiana; Wetherill, Leah; Vinci-Booher, Sophia et al. (2012) Relation over time between facial measurements and cognitive outcomes in fetal alcohol-exposed children. Alcohol Clin Exp Res 36:1634-46

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