This project will focus on several of the specific research areas targeted in the Request for Application (RFA) including: a) improvements in the diagnosis of FASD, b) enhanced understanding of FASD dysmorphology through 2-D and 3-D image analysis, and c) earlier case identification. We will work collaboratively with each of the clinical projects recruiting the subjects from whom we will obtain facial images. In addition, we will compare results with the two basic science projects that are focusing on the use of animal models. Lastly, we will rely on the two cores for subject evaluation (Dysmorphology) and data management (Bioinformatics). Throughout this application and within the Consortium - there is a strong focus on novel methods to better understand and recognize the spectrum of deficits resulting from prenatal alcohol exposure. Furthermore, replication of results is a key component of our study design. We seek not only to replicate key findings within the same research population - but to also extend the results to other populations of differing ethnicity and diversiy. Such worldwide replication is only possible through an international consortium like CIFASD. Results from this study will then be used as the basis for new screening tools that can be used by clinicians. To accomplish our goals, we propose the following specific aims: 1) Develop a screening tool that will utilize the data from the 3D facial images and support accurate identification of individuals with a high likelihood of alcohol exposure. 2) Recruit and analyze facial imaging data from very young populations to develop a screening tool that accurately identifies high risk individuals for future intervention. 3) Combine face images, neurobehavioral data and brain images to identify common pathways and hence improve diagnosis of prenatal alcohol exposure. 4) Extend existing and develop novel techniques and associated software to cope with demands of larger datasets and more diverse comparison of controls, alcohol exposed and other developmentally delayed subjects while accommodating multiple anatomical images per subject 5) Extend preliminary genetic studies through collection of DNA samples for new subjects and focused analysis to replicate candidate genes identified in basic science components.

Public Health Relevance

The goal of this project and the Consortium as a whole is to develop new methods to better understand and recognize the spectrum of deficits that result from prenatal alcohol exposure. This project is focused on the use of facial images as the primary approach to this question. We will use facial images to improve the diagnosis of fetal alcohol spectrum disorders and also develop methods to identify these children at very early ages - so as to allow early intervention to improve outcome.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AA014809-11
Application #
8668822
Study Section
Special Emphasis Panel (ZAA1-CC (02))
Program Officer
Dunty, Jr, William
Project Start
2003-09-30
Project End
2017-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
11
Fiscal Year
2014
Total Cost
$301,422
Indirect Cost
$71,762
Name
Indiana University-Purdue University at Indianapolis
Department
Genetics
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Kodali, Vikas N; Jacobson, Joseph L; Lindinger, Nadine M et al. (2017) Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol. Alcohol Clin Exp Res 41:334-344
Jacobson, Sandra W; Jacobson, Joseph L; Molteno, Christopher D et al. (2017) Heavy Prenatal Alcohol Exposure is Related to Smaller Corpus Callosum in Newborn MRI Scans. Alcohol Clin Exp Res 41:965-975
Suttie, Michael; Wetherill, Leah; Jacobson, Sandra W et al. (2017) Facial Curvature Detects and Explicates Ethnic Differences in Effects of Prenatal Alcohol Exposure. Alcohol Clin Exp Res 41:1471-1483
Ibrahim, Amel; Suttie, Michael; Bulstrode, Neil W et al. (2016) Combined soft and skeletal tissue modelling of normal and dysmorphic midface postnatal development. J Craniomaxillofac Surg 44:1777-1785
Carter, R Colin; Jacobson, Joseph L; Molteno, Christopher D et al. (2016) Fetal Alcohol Growth Restriction and Cognitive Impairment. Pediatrics 138:
Hammond, Peter; McKee, Shane; Suttie, Michael et al. (2014) Opposite effects on facial morphology due to gene dosage sensitivity. Hum Genet 133:1117-25
McCarthy, Neil; Wetherill, Leah; Lovely, C Ben et al. (2013) Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development 140:3254-65
Suttie, Michael; Foroud, Tatiana; Wetherill, Leah et al. (2013) Facial dysmorphism across the fetal alcohol spectrum. Pediatrics 131:e779-88
Swaminathan, Shanker; Shen, Li; Risacher, Shannon L et al. (2012) Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Brain Imaging Behav 6:1-15
Foroud, Tatiana; Wetherill, Leah; Vinci-Booher, Sophia et al. (2012) Relation over time between facial measurements and cognitive outcomes in fetal alcohol-exposed children. Alcohol Clin Exp Res 36:1634-46

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