This application is in response to a Request for Application (RFA-HD-10-018) to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FASD, and to determine how these different outcomes are inter-related, The proposed research will be conducted by the investigators the Prenatal Alcohol, SIDS and Stillbirth (PASS) Research Network in a cooperative agreement with NICHD and NIAAA. This research involves the collaboration of: 1) two comprehensive clinical sites serving populations that are high risk for prenatal alcohol exposure, SIDS, and stillbirth, i.e. the American Indians in the Northern Plains and the Cape Coloured in Cape Town, South Africa;2) a central Developmental Biology and Pathology Centre (DBPC);3) a central Data Coordinating and Analysis Center (DCAC);4) a central Physiology Assessment Center (PAC);and 5) program scientists and officers at the NICHD and NIAAA. The mission of our site is to accomplish the 9 Specific Aims of the Safe Passage Study through the recruitment and enrollment of 7,000 women and the performance of all of the hypothesis-driven study protocols involving the maternal/fetal dyads. The SCCS is overseeing the performance and analysis of Specific Aim 3.
This aim i s to determine the role of prenatal alcohol exposure, as potentially modified by other environmental, genetic, and placental factors, upon the facial features, somatic growth, and neurological/brain development in the fetus and infant utilizing fetal ultrasonography and infant facial imaging and standardized feature assessment. We will test the hypotheses that: 1) prenatal alcohol exposure adversely impacts facial, somatic, and/or brain growth in the human fetus as early as 20-24 gestational weeks, i.e., the earliest time-point examined by us;2) prenatal alcohol exposure is associated with facial dysmorphology that is identified by imaging of the face as early as 20-24 weeks and remains present at 1 postnatal month and 12 postnatal months;and 3) this alcohol toxicity is modified by other environmental and placental factors, such as maternal nutrition, maternal smoking, and placental perfusion failure.

Public Health Relevance

Heavy drinking during pregnancy in many disadvantaged communities in South Africa is of great concern. This study will identify additional adverse effects of alcohol on the placenta and developing fetus. More information on the adverse effects will strengthen campaigns against drinking during pregnancy.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01AA016501-06
Application #
8204068
Study Section
Special Emphasis Panel (ZAA1-GG (02))
Program Officer
Dunty, Jr, William
Project Start
2006-09-30
Project End
2016-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
6
Fiscal Year
2011
Total Cost
$1,304,105
Indirect Cost
Name
Stellenbosch University Tygerberg Campus
Department
Type
DUNS #
569118040
City
Tygerberg
State
Country
South Africa
Zip Code
7505
Dukes, Kimberly; Tripp, Tara; Petersen, Julie et al. (2017) A modified Timeline Followback assessment to capture alcohol exposure in pregnant women: Application in the Safe Passage Study. Alcohol 62:17-27
Odendaal, Hein; Groenewald, Coen; Hankins, Gary D V et al. (2017) Transabdominal recordings of fetal heart rate in extremely small fetuses. J Matern Fetal Neonatal Med :1-4
Geldenhuys, Elaine; Coldrey, Jean; Wright, Colleen et al. (2017) Fetal foot length at delivery as a tool for determining gestation length in non-macerated stillbirths. Int J Gynaecol Obstet 138:107-112
Dukes, Kimberly; Tripp, Tara; Willinger, Marian et al. (2017) Drinking and smoking patterns during pregnancy: Development of group-based trajectories in the Safe Passage Study. Alcohol 62:49-60
Guo, Shaofeng; Wang, Runsheng; Mao, Dongyuan et al. (2017) Anomalous random telegraph noise in nanoscale transistors as direct evidence of two metastable states of oxide traps. Sci Rep 7:6239
Myers, Michael M; Elliott, Amy J; Odendaal, Hein J et al. (2017) Cardiorespiratory physiology in the safe passage study: protocol, methods and normative values in unexposed infants. Acta Paediatr 106:1260-1272
Haynes, Robin L; Folkerth, Rebecca D; Paterson, David S et al. (2016) Serotonin Receptors in the Medulla Oblongata of the Human Fetus and Infant: The Analytic Approach of the International Safe Passage Study. J Neuropathol Exp Neurol :
Angal, Jyoti; Petersen, Julie M; Tobacco, Deborah et al. (2016) Ethics Review for a Multi-Site Project Involving Tribal Nations in the Northern Plains. J Empir Res Hum Res Ethics 11:91-6
Dempers, Johan J; Coldrey, Jean; Burger, Elsie H et al. (2016) The Institution of a Standardized Investigation Protocol for Sudden Infant Death in the Eastern Metropole, Cape Town, South Africa,. J Forensic Sci 61:1508-1514
Himes, Sarah K; Dukes, Kimberly A; Tripp, Tara et al. (2015) Clinical sensitivity and specificity of meconium fatty acid ethyl ester, ethyl glucuronide, and ethyl sulfate for detecting maternal drinking during pregnancy. Clin Chem 61:523-32

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