A key objective of the INIA programs is to transform research on causes, prevention, and treatment of alcoholism. Integration of data sets and analytic methods across a broad spectrum of research is critical to success. This INIA UOI Core application is built on the success of several powerful INIA web services and data resources, including GeneNetwork, WebGestalt, and the Ontological Discovery Environment (ODE). However, our aims in this renewal are a direct outgrowth of rapid changes in genomics and neuroscience, in particular, next-generation sequencing. A theme of this core is innovation by integration. The far more pervasive use of web services in neuroscience over the last five years - Allen Brain Atlas, DAVID, ODE, Galaxy, GeneNetwork, GeneWiki, KEGG, and the Neuroscience Information Framework - represents a great research opportunity for our INIA teams. But these resources often have a steep learning curve and are difficult to use together. One of our goals is to assemble these resources together with large new data sets in a context useful to NIAAA researchers. The INIA Translational Web Services core has these aims: (1) Process, analyze, and distribute massive array and next-generation data sets for both INIA consortia;(2) Integrate INIA consortia data sets from rodents, non-human primates, and humans into GeneNetwork and significantly enhance tools for bidirectional translational queries;(3) Provide database support, training, and documentation in bioinformatics, genetics, and next-gen genomic tools to other INIA projects and cores.

Public Health Relevance

This INIA Bioinformatics Core will provide crucial support to both INIAs for data integration. Our special emphasis is on securing and analyzing massive genomic data sets generated using arrays and next generation sequencing systems. We are also building tools to enable much more facile translation of discoveries from animal models of alcoholism to human populations and groups who are at risk.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AA016662-07
Application #
8423712
Study Section
Special Emphasis Panel (ZAA1-DD (51))
Program Officer
Grandison, Lindsey
Project Start
2007-02-20
Project End
2017-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
7
Fiscal Year
2013
Total Cost
$182,517
Indirect Cost
$78,203
Name
University of Tennessee Health Science Center
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
Neuner, Sarah M; Garfinkel, Benjamin P; Wilmott, Lynda A et al. (2016) Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging. Neurobiol Aging 46:58-67
Alam, Gelareh; Miller, Diane B; O'Callaghan, James P et al. (2016) MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. Neurotoxicology 55:40-7
van der Vaart, Andrew D; Wolstenholme, Jennifer T; Smith, Maren L et al. (2016) The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort. Alcohol :
Lopez, Marcelo F; Miles, Michael F; Williams, Robert W et al. (2016) Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort. Alcohol :
Rinker, Jennifer A; Fulmer, Diana B; Trantham-Davidson, Heather et al. (2016) Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol :
Shi, Xiao; Walter, Nicole A R; Harkness, John H et al. (2016) Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function. PLoS One 11:e0152581
Porcu, Patrizia; O'Buckley, Todd K; Lopez, Marcelo F et al. (2016) Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains. Alcohol :
Wang, Xusheng; Pandey, Ashutosh K; Mulligan, Megan K et al. (2016) Joint mouse-human phenome-wide association to test gene function and disease risk. Nat Commun 7:10464
Delprato, A; Bonheur, B; Algéo, M-P et al. (2015) Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav 14:591-606
Padula, Audrey E; Griffin 3rd, William C; Lopez, Marcelo F et al. (2015) KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology 40:1928-39

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