In response to RFA-AA-12-006, this application proposes the Pittsburgh Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA: Pittsburgh) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 Pittsburgh subjects (N=680 from all sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to toxic alcohol effects. In addition, NCANDA: Pittsburgh will collaborate on two supplemental studies. We will collaborate with NCANDA: Duke in a study utilizing functional MRI to examine cerebral activation during a reward modulated anti-saccade task to study alcohol effects on reward responding and behavioral inhibition. We will also collaborate with NCANDA: SRI in a laboratory sleep study to examine the effects of alcohol on adolescent sleep architecture. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at elevated risk for an alcohol use disorder.

Public Health Relevance

The National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA) will use multimodal brain imaging, neuropsychological testing and clinical assessments in a large adolescents sample followed over four years to determine neurodevelopmental risks for problematic alcohol use and alcohol effects on adolescent brain development. In addition to contributing to this goal, N-CANDA: Pittsburgh will also determine the effects of adolescent alcohol use on sleep architecture and the neurobiological foundations of behavioral inhibition. This information may be used to advance the prevention and treatment of adolescent alcohol use disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AA021690-03
Application #
8693887
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Matochik, John A
Project Start
2012-09-05
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Pohl, Kilian M; Sullivan, Edith V; Rohlfing, Torsten et al. (2016) Harmonizing DTI measurements across scanners to examine the development of white matter microstructure in 803 adolescents of the NCANDA study. Neuroimage 130:194-213
Sullivan, Edith V; Brumback, Ty; Tapert, Susan F et al. (2016) Cognitive, emotion control, and motor performance of adolescents in the NCANDA study: Contributions from alcohol consumption, age, sex, ethnicity, and family history of addiction. Neuropsychology 30:449-73
Li, James J; Chung, Tammy A; Vanyukov, Michael M et al. (2015) A Hierarchical Factor Model of Executive Functions in Adolescents: Evidence of Gene-Environment Interplay. J Int Neuropsychol Soc 21:62-73
Zhai, Zu Wei; Pajtek, Stefan; Luna, Beatriz et al. (2015) Reward-Modulated Response Inhibition, Cognitive Shifting, and the Orbital Frontal Cortex in Early Adolescence. J Res Adolesc 25:753-764
Creswell, Kasey G; Chung, Tammy; Wright, Aidan G C et al. (2015) Personality, negative affect coping, and drinking alone: a structural equation modeling approach to examine correlates of adolescent solitary drinking. Addiction 110:775-83
Creswell, Kasey G; Chung, Tammy; Clark, Duncan B et al. (2015) Solitary cannabis use in adolescence as a correlate and predictor of cannabis problems. Drug Alcohol Depend 156:120-5
Hasler, Brant P; Soehner, Adriane M; Clark, Duncan B (2015) Sleep and circadian contributions to adolescent alcohol use disorder. Alcohol 49:377-87
Brown, Sandra A; Brumback, Ty; Tomlinson, Kristin et al. (2015) The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): A Multisite Study of Adolescent Development and Substance Use. J Stud Alcohol Drugs 76:895-908
Long, E C; Hill, J; Luna, B et al. (2015) Disruptive behavior disorders and indicators of disinhibition in adolescents: The BRIEF-SR, anti-saccade task, and D-KEFS color-word interference test. J Adolesc 44:182-90
Chung, Tammy; Ferrell, Robert; Clark, Duncan B (2015) Indirect association of DAT1 genotype with executive function through white matter volume in orbitofrontal cortex. Psychiatry Res 232:76-83

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