This application requests funds for the Coordinating Center to extend follow-up of the functional and cognitive outcomes of old and very-old persons who have received cognitive interventions as part of the ACTIVE (Advanced Cognitive Training for independent and Vital Elderly) study. Findings at five years indicate the effects of the intervention on cognitive abilities are durable and that these intervention effects have transferred to maintenance of IADL function as hypothesized.
The Specific Aims of this extended follow-up are to: 1) To determine if the cognitive interventions continue to have protective effects up to 10 years after initial training: a) basic cognitive abilities of memory, reasoning, and speed or processing;b) self-reported and performance-based instrumental activities of daily living;and c) health-related quality of life. 2) To determine if the cognitive interventions have beneficial effects on the distal outcomes of driving safety, personal care activities of daily living, health service utilization, and mortality. 3) To examine heath, genetic and cognitive moderators in individual response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype. 4) To estimate and project the effects of ACTIVE training to the general population of older adults by linking the measures and outcomes of ACTIVE to the Health and Retirement Study. This application affords a unique opportunity to prospectively study lagged effects of three types of cognitive interventions on functional decline in this well-characterized cohort that, given its advancing age, is now at imminent risk for both IADL and ADL decline. We will be able to test the basic question in this study: For older adults exposed to these cognitive interventions, can disability in the performance of key everyday activities be delayed and independence maintained as subjects age into their 80s. We estimate power to detect effect sizes of 0.2 over 10 years for the cognitive abilities, everyday problem solving, and everyday speed and an effect size of 0.4 for everyday functioning. The ACTIVE study will determine if cognitive training can help older adults to continue functioning and living independently for a longer period of time.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG014282-11
Application #
7800925
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Nielsen, Lisbeth
Project Start
1996-09-30
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2013-04-30
Support Year
11
Fiscal Year
2010
Total Cost
$350,526
Indirect Cost
Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472
Edwards, Jerri D; Xu, Huiping; Clark, Daniel O et al. (2017) Speed of processing training results in lower risk of dementia. Alzheimers Dement (N Y) 3:603-611
Meyer, Oanh L; Sisco, Shannon M; Harvey, Danielle et al. (2017) Neighborhood Predictors of Cognitive Training Outcomes and Trajectories in ACTIVE. Res Aging 39:443-467
Parisi, Jeanine M; Gross, Alden L; Marsiske, Michael et al. (2017) Control beliefs and cognition over a 10-year period: Findings from the ACTIVE trial. Psychol Aging 32:69-75
Ross, Lesley A; Edwards, Jerri D; O'Connor, Melissa L et al. (2016) The Transfer of Cognitive Speed of Processing Training to Older Adults' Driving Mobility Across 5 Years. J Gerontol B Psychol Sci Soc Sci 71:87-97
Choi, Moon; O'Connor, Melissa L; Mingo, Chivon A et al. (2016) Gender and Racial Disparities in Life-Space Constriction Among Older Adults. Gerontologist 56:1153-1160
Phillips, Christine B; Sprague, Briana N; Freed, Sara A et al. (2016) Longitudinal Associations Between Changes in Physical Function and Driving Mobility Behaviors of Older Adults. Transp Res Rec 2584:70-76
Zahodne, Laura B; Meyer, Oanh L; Choi, Eunhee et al. (2015) External locus of control contributes to racial disparities in memory and reasoning training gains in ACTIVE. Psychol Aging 30:561-72
Payne, Brennan R; Gross, Alden L; Parisi, Jeanine M et al. (2014) Modelling longitudinal changes in older adults' memory for spoken discourse: findings from the ACTIVE cohort. Memory 22:990-1001
Yam, Anna; Gross, Alden L; Prindle, John J et al. (2014) Ten-year longitudinal trajectories of older adults' basic and everyday cognitive abilities. Neuropsychology 28:819-28
Thomas, Kelsey R; Marsiske, Michael (2014) Verbal prompting to improve everyday cognition in MCI and unimpaired older adults. Neuropsychology 28:123-34

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