This is the Competing Continuation application of the National Alzheimer's Coordinating Center (NACC). Between about 1984 and 1997, no data were centrally collected for the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging. Establishment of an interim data center and a Minimum Data Set in about 1997 led to the NIA issuance of an RFA for an Alzheimer's Disease Data Coordinating Center. Since receiving the interim center Minimum Data Set (MDS), NACC has successfully refined and expanded the overall database, reduced missing data, increased data validity, expanded neuropathological data, added Center-wide data surveys, and increased accessibility to the data through the use of web-based data access and entry. The capabilities provided for use of combined ADC data have not been experienced by the ADCs prior to the establishment of NACC. With over 60,000 subjects, this is currently the largest Alzheimer's and related disorders database ever assembled in the U.S. NACC was additionally charged with increasing collaboration between the ADCs, not only through the use of the MDS but also through the promotion of investigator-initiated collaborative projects and the provision of statistical, methodological and database management consulting to the ADCs and for the collaborative projects. In the next grant cycle, NACC will continue to expand on these efforts. The Uniform Data Set (UDS) has now been mandated for use in all ADCs by NIA. NACC will build a database structure to implement the UDS, collect the data and integrate it seamlessly with the existing data. NACC will develop a means of capturing referral source and selection method data for all new UDS enrollees. These data will help describe and increase the external validity of analyses which use the database and will form the basis for ADCs to select the most comparable controls for their cases. NACC will continue its successful collaborative project program and will also encourage small secondary data analysis studies from junior investigators. NACC will continue design and analysis consulting, and expand its efforts to increase communication and collaboration through the NACC web site. NACC will also conduct its own data analyses and develop methodological research relevant to the needs of the ADCs and research in general. Finally, NACC will continue its administrative coordinating activities to facilitate meetings of the ADC Directors and Core Leaders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG016976-07
Application #
6922807
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (M5))
Program Officer
Phelps, Creighton H
Project Start
1999-07-01
Project End
2009-06-30
Budget Start
2005-07-15
Budget End
2006-06-30
Support Year
7
Fiscal Year
2005
Total Cost
$2,815,420
Indirect Cost
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Raghavan, Neha S; Brickman, Adam M; Andrews, Howard et al. (2018) Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease. Ann Clin Transl Neurol 5:832-842
Irimata, Katherine E; Dugger, Brittany N; Wilson, Jeffrey R (2018) Impact of the Presence of Select Cardiovascular Risk Factors on Cognitive Changes among Dementia Subtypes. Curr Alzheimer Res 15:1032-1044
Brent, Robert J (2018) The value of a year's general education for reducing the symptoms of dementia. Appl Econ 50:2812-2823
Gnjidic, Danijela; Agogo, George O; Ramsey, Christine M et al. (2018) The Impact of Dementia Diagnosis on Patterns of Potentially Inappropriate Medication Use Among Older Adults. J Gerontol A Biol Sci Med Sci 73:1410-1417
Lancour, Daniel; Naj, Adam; Mayeux, Richard et al. (2018) One for all and all for One: Improving replication of genetic studies through network diffusion. PLoS Genet 14:e1007306
Deming, Yuetiva; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol 136:857-872
Bilbrey, Ann Choryan; Humber, Marika B; Plowey, Edward D et al. (2018) The Impact of Latino Values and Cultural Beliefs on Brain Donation: Results of a Pilot Study to Develop Culturally Appropriate Materials and Methods to Increase Rates of Brain Donation in this Under-Studied Patient Group. Clin Gerontol 41:237-248
Hohman, Timothy J; Dumitrescu, Logan; Barnes, Lisa L et al. (2018) Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol 75:989-998
Burke, Shanna L; Maramaldi, Peter; Cadet, Tamara et al. (2018) Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry 33:200-211
Kim, Julia; Schweizer, Tom A; Fischer, Corinne E et al. (2018) Psychosis in ""Cognitively Asymptomatic"" Elderly Subjects is Associated With Neuritic Plaque Load, Not Neurofibrillary Tangles. Alzheimer Dis Assoc Disord 32:185-189

Showing the most recent 10 out of 552 publications