University of Florida Administrative Coordinating Center (ACC) and Field Center (Marco Pahor, MD), The proposed study will be conducted in the Department of Aging and Geriatric Research and the Institute of Aging (IOA) - Claude Pepper Older Americans Independence Center (OAIC). The research program of the IOA-OAIC focuses on the etiology, prevention and rehabilitation of cognitive and physical disability. The leading investigators in the IOA program have yrs of experience in NIH funded clinical research trials and the requisite skills to manage complex research enterprises. Marco Pahor, MD, PI of the proposed study, of the Administrative Coordinating Center and UF Field center PI, is Professor and Chair of the Department of Aging and Geriatric Research and Director of the UF Institute on Aging. He is a nationally and internationally known scientist in the areas of aging, disability and cardiovascular disease in population-based studies. He has over 27 years of experience in geriatrics, epidemiology and clinical trials, with special expertise in the area of physical disability in older populations. He has an excellent record of publications, leadership and administrative skills. He has authored or co-authored over 230 publications in leading peer reviewed journals in areas relevant to this application. He has extensive expertise in directing interdisciplinary research teams, such as LIFE-P, the UF and WFUHS OAIC and the UF Institute on Aging, and in planning, conducting and/or analyzing data from large NIH funded randomized controlled trials and epidemiologic studies in older populations, including HABC^9, WHAS10'15, EPESE16""""""""49, SHEP50'60, FAST61'64 ADAPT,65* and LIFE-P.68'72 With the highly successful conduction and completion of LIFE-P, Dr. Pahor has demonstrated excellent leadership and administrative skills and he has proven his qualifications as a strong leader for LIFE-M.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project--Cooperative Agreements (U01)
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Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (O3))
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University of Florida
United States
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Hughes, Timothy M; Sink, Kaycee M (2016) Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future. Am J Hypertens 29:149-57
Dotson, V M; Hsu, F C; Langaee, T Y et al. (2016) Genetic Moderators of the Impact of Physical Activity on Depressive Symptoms. J Frailty Aging 5:6-14
Bann, David; Chen, Haiying; Bonell, Chris et al. (2016) Socioeconomic differences in the benefits of structured physical activity compared with health education on the prevention of major mobility disability in older adults: the LIFE study. J Epidemiol Community Health 70:930-3
Aubertin-Leheudre, Mylène; Anton, Stephen; Beavers, Daniel P et al. (2016) Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. J Am Med Dir Assoc :
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Gill, Thomas M; Pahor, Marco; Guralnik, Jack M et al. (2016) Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). BMJ 352:i245
Groessl, Erik J; Kaplan, Robert M; Castro Sweet, Cynthia M et al. (2016) Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability. J Gerontol A Biol Sci Med Sci 71:656-62
Marsh, Anthony P; Applegate, William B; Guralnik, Jack M et al. (2016) Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc 64:933-43
Kheirkhahan, Matin; Tudor-Locke, Catrine; Axtell, Robert et al. (2016) Actigraphy features for predicting mobility disability in older adults. Physiol Meas 37:1813-1833
Vaz Fragoso, Carlos A; Beavers, Daniel P; Anton, Stephen D et al. (2016) Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations. J Am Geriatr Soc 64:501-9

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