University of Florida Administrative Coordinating Center (ACC) and Field Center (Marco Pahor, MD), The proposed study will be conducted in the Department of Aging and Geriatric Research and the Institute of Aging (IOA) - Claude Pepper Older Americans Independence Center (OAIC). The research program of the IOA-OAIC focuses on the etiology, prevention and rehabilitation of cognitive and physical disability. The leading investigators in the IOA program have yrs of experience in NIH funded clinical research trials and the requisite skills to manage complex research enterprises. Marco Pahor, MD, PI of the proposed study, of the Administrative Coordinating Center and UF Field center PI, is Professor and Chair of the Department of Aging and Geriatric Research and Director of the UF Institute on Aging. He is a nationally and internationally known scientist in the areas of aging, disability and cardiovascular disease in population-based studies. He has over 27 years of experience in geriatrics, epidemiology and clinical trials, with special expertise in the area of physical disability in older populations. He has an excellent record of publications, leadership and administrative skills. He has authored or co-authored over 230 publications in leading peer reviewed journals in areas relevant to this application. He has extensive expertise in directing interdisciplinary research teams, such as LIFE-P, the UF and WFUHS OAIC and the UF Institute on Aging, and in planning, conducting and/or analyzing data from large NIH funded randomized controlled trials and epidemiologic studies in older populations, including HABC^9, WHAS10'15, EPESE16""""""""49, SHEP50'60, FAST61'64 ADAPT,65* and LIFE-P.68'72 With the highly successful conduction and completion of LIFE-P, Dr. Pahor has demonstrated excellent leadership and administrative skills and he has proven his qualifications as a strong leader for LIFE-M.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project--Cooperative Agreements (U01)
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Study Section
Special Emphasis Panel (ZAG1)
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University of Florida
United States
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Santanasto, Adam J; Glynn, Nancy W; Lovato, Laura C et al. (2017) Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility. J Am Geriatr Soc 65:1427-1433
Fielding, Roger A; Guralnik, Jack M; King, Abby C et al. (2017) Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: Results from the LIFE study randomized trial. PLoS One 12:e0182155
Kritchevsky, Stephen B; Lovato, Laura; Handing, Elizabeth P et al. (2017) Exercise's effect on mobility disability in older adults with and without obesity: The LIFE study randomized clinical trial. Obesity (Silver Spring) 25:1199-1205
Chen, Haiying; Ambrosius, Walter T; Murphy, Terrence E et al. (2017) Imputation of Gait Speed for Noncompleters in the 400-Meter Walk: Application to the Lifestyle Interventions for Elders Study. J Am Geriatr Soc 65:2566-2571
Wanigatunga, Amal A; Tudor-Locke, Catrine; Axtell, Robert S et al. (2017) Effects of a Long-Term Physical Activity Program on Activity Patterns in Older Adults. Med Sci Sports Exerc 49:2167-2175
Layne, Andrew S; Hsu, Fang-Chi; Blair, Steven N et al. (2017) Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Arch Phys Med Rehabil 98:11-24.e3
King, Abby C; Salvo, Deborah; Banda, Jorge A et al. (2017) Preserving older adults' routine outdoor activities in contrasting neighborhood environments through a physical activity intervention. Prev Med 96:87-93
Reid, K F; Walkup, M P; Katula, J A et al. (2017) Cognitive Performance Does not Limit Physical Activity Participation in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). J Prev Alzheimers Dis 4:44-50
Manini, Todd M; Beavers, Daniel P; Pahor, Marco et al. (2017) Effect of Physical Activity on Self-Reported Disability in Older Adults: Results from the LIFE Study. J Am Geriatr Soc 65:980-988
Aubertin-Leheudre, Mylène; Anton, Stephen; Beavers, Daniel P et al. (2017) Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study. J Am Med Dir Assoc 18:312-319

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