The Osteoporotic Fractures in Men (MrOS) study was formed primarily to quantify the determinants of fracture in men. Importantly, the MrOS cohort also provides a seminal opportunity to study men as they progress through a critical period of life in which problems of aging remain poorly understood. In 2000-2002, 5995 community-dwelling men ages 65 years and older (mean age: 72 years at baseline) were enrolled from 6 diverse US communities. The study is directed by the Administrative Center in Portland OR, and study wide coordination, communication and data management occurs at the Coordinating Center in San Francisco CA. After 5 years of follow-up, participant retention is excellent (99% of those alive remain active). We propose a new clinic visit and continued follow-up of the cohort to expand our understanding of risk factors for falls, fractures (particularly hip fracture) and other consequences of aging. At baseline, both areal (from DXA) and volumetric (from QCT) skeletal assessments were obtained. We propose to repeat the same assessments in the planned visit to identify the densitometric and biomechanical risk factors for hip fracture, as well as to characterize bone geometry changes that underlie skeletal fragility. Further, we will use the QCT scans to quantify femoral strength by finite element modeling (FEM), and assess the usefulness of FEM for fracture prediction. Additional follow-up of the cohort and repeat measures of muscle strength (grip strength, leg power), physical performance (gait speed, chair stands, and narrow walk), and self-reported physical activity will enable us to establish the extent and nature of change in activity and physical performance, identify biological predictors of these changes, and clarify the possibly joint effects of physical activity and physical performance on fracture risk. To objectively quantify physical activity we propose to obtain accelerometry measures at the new clinic visit. Using serum archived at baseline, we will test the hypothesis that renal function, vitamin D, parathyroid hormone have important effects on skeletal health, physical function and fracture risk, and will determine if lower sex steroid levels increase men's risk of skeletal deterioration and fracture, decline in physical function, and deterioration in quality of life. Study leadership will continue at the Administrative Center in Portland and management of study operations will occur at the Coordinating Center in San Francisco. Combined with the considerable data and biologic specimens already collected, additional measures and extended follow-up in the MrOS cohort allows us to expand the understanding of hip fractures, the most devastating type of fracture in men, as well as address other health issues of compelling public health and clinical importance to older US men.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AG027810-06
Application #
8106120
Study Section
Special Emphasis Panel (ZAR1-EHB-H (M1))
Program Officer
Sherman, Sherry
Project Start
2006-09-01
Project End
2013-06-30
Budget Start
2011-08-01
Budget End
2013-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$463,993
Indirect Cost
Name
Oregon Health and Science University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Hart, Allyson; Blackwell, Terri L; Paudel, Misti L et al. (2017) Cystatin C and the Risk of Frailty and Mortality in Older Men. J Gerontol A Biol Sci Med Sci 72:965-970
Robinson-Cohen, Cassianne; Lutsey, Pamela L; Kleber, Marcus E et al. (2017) Genetic Variants Associated with Circulating Parathyroid Hormone. J Am Soc Nephrol 28:1553-1565
Pollack, Lauren R; Litwack-Harrison, Stephanie; Cawthon, Peggy M et al. (2017) Patterns and Predictors of Frailty Transitions in Older Men: The Osteoporotic Fractures in Men Study. J Am Geriatr Soc 65:2473-2479
Raman, Dileep; Kaffashi, Farhad; Lui, Li-Yung et al. (2017) Polysomnographic Heart Rate Variability Indices and Atrial Ectopy Associated with Incident Atrial Fibrillation Risk in Older Community-dwelling Men. JACC Clin Electrophysiol 3:451-460
Faber, B G; Baird, D; Gregson, C L et al. (2017) DXA-derived hip shape is related to osteoarthritis: findings from in the MrOS cohort. Osteoarthritis Cartilage 25:2031-2038
Cawthon, Peggy M; Lui, Li-Yung; Taylor, Brent C et al. (2017) Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men: The Osteoporotic Fractures in Men Study. J Gerontol A Biol Sci Med Sci 72:1383-1389
Baumgartner, Christine; da Costa, Bruno R; Collet, Tinh-Hai et al. (2017) Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation. Circulation 136:2100-2116
Swanson, Christine M; Kohrt, Wendy M; Buxton, Orfeu M et al. (2017) The importance of the circadian system & sleep for bone health. Metabolism :
Ben-Avraham, Dan; Karasik, David; Verghese, Joe et al. (2017) The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY) 9:209-246
Kassem, Ahmed M; Ganguli, Mary; Yaffe, Kristine et al. (2017) Anxiety symptoms and risk of cognitive decline in older community-dwelling men. Int Psychogeriatr 29:1137-1145

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