In previous research wide variations have been found in both healthcare spending and in health outcomes, with little correlation between the two. These studies were limited to cross-sectional analysis, and tell little about the dynamic process by which these patterns arise. One hypothesis is that variation across regions in rates of technology diffusion, whether for highly effective treatments (with a large impact on health outcomes) or for expensive treatments with unknown value (with a large impact on expenditures), can explain the observed cross-sectional patterns of spending and outcomes. In this proposal, Aim 1 seeks to better understand the diffusion of highly effective healthcare such as hemoglobin A1c (HbA1c) tests for blood glucose control among diabetic patients. Using the national Doximity database on every physician in the U.S., along with information about physician-hospital networks (PHN) and physician social networks, the research team will test why HbA1c diffused so rapidly (and among all racial and ethnic groups) in some areas but not others. They will also test whether more rapid diffusion of HbA1c reduced rates of neuropathy, retinopathy, and amputation.
Aim 2 focuses on the diffusion of generally beneficial treatments but where the treatment can actually harm specific types of patients. Two examples are considered: the rapid growth in implantable cardioverter defibrillators (ICDs), and the growth in new and expensive anticoagulants - dabigatran, apixaban and rivaroxaban.
Aim 3 studies the opposite of diffusion - """"""""exnovation"""""""" or a retreat from use - to ask how physician-hospital networks and regions scaled back on treatments newly found to have poor value for subgroups of patients. The proposal considers two specific treatments: the sharp reduction in carotid endarterectomy (both surgery and stents), and the decline in the use of Rosiglitazone (Avandia), an anti-diabetic drug, following a 2007 publication demonstrating serious cardiovascular risks. In these cases, the most effective exnovation patterns should experience the largest drop in use for the less appropriate patients.
Aim 4 examines the diffusion of treatments with unknown or even adverse consequences, such as the rapid growth in some regions (but not others) in ICU bed capacity. The research team will study the network and diffusion patterns for """"""""extramedical"""""""" treatments - illegal behavior motivated by profit and with no benefit for patients, with one example being the rise and fall of immunoglobulin infusions in 2002-2005. Finally, the research group will use results from these four aims to return to the central hypothesis: can observed differences in treatment-specific diffusion explain observed patterns in regional variations in health outcomes and spending?

Public Health Relevance

Despite the high and variable cost of healthcare in the U.S., there remain persistent and large shortfalls in the quality of care. This study seeks to explain why these variations exist by focusing on patterns of diffusion of new healthcare technologies. Using a national database on physician characteristics, measures of social and practice networks, and clinical registry data linked to Medicare claims data, we seek to understand why some healthcare providers are better able to adopt high-quality care quickly - and use it effectively - and why some healthcare providers instead adopt the most costly and least effective treatments.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-HDM-R (51))
Program Officer
Baker, Colin S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Schools of Arts and Sciences
United States
Zip Code
Suckow, Bjoern D; Newhall, Karina A; Bekelis, Kimon et al. (2016) Hemoglobin A1c Testing and Amputation Rates in Black, Hispanic, and White Medicare Patients. Ann Vasc Surg 36:208-217
Moen, Erika L; Austin, Andrea M; Bynum, Julie P et al. (2016) An analysis of patient-sharing physician networks and implantable cardioverter defibrillator therapy. Health Serv Outcomes Res Methodol 16:132-153
Wallaert, Jessica B; Nolan, Brian W; Stone, David H et al. (2016) Physician specialty and variation in carotid revascularization technique selected for Medicare patients. J Vasc Surg 63:89-97
Bekelis, Kimon; Gottlieb, Dan; Su, Yin et al. (2016) Medicare expenditures for elderly patients undergoing surgical clipping or endovascular intervention for unruptured cerebral aneurysms. J Neurointerv Surg :
Bekelis, Kimon; Gottlieb, Dan; Su, Yin et al. (2016) Surgical clipping versus endovascular coiling for elderly patients presenting with subarachnoid hemorrhage. J Neurointerv Surg 8:913-8
Newhall, Karina; Spangler, Emily; Dzebisashvili, Nino et al. (2016) Amputation Rates for Patients with Diabetes and Peripheral Arterial Disease: The Effects of Race and Region. Ann Vasc Surg 30:292-8.e1
Meara, Ellen; Horwitz, Jill R; Powell, Wilson et al. (2016) State Legal Restrictions and Prescription-Opioid Use among Disabled Adults. N Engl J Med 375:44-53
Bekelis, Kimon; Gottlieb, Daniel J; Su, Yin et al. (2016) Comparison of clipping and coiling in elderly patients with unruptured cerebral aneurysms. J Neurosurg :1-8
Newhall, Karina; Gottlieb, Daniel J; Stone, David H et al. (2016) Trends in the Diagnosis and Outcomes of Traumatic Carotid and Vertebral Artery Dissections among Medicare Beneficiaries. Ann Vasc Surg 36:145-152
Roth, Gregory A; Poole, Jeanne E; Zaha, Rebecca et al. (2016) Use of Guideline-Directed Medications for Heart Failure Before Cardioverter-Defibrillator Implantation. J Am Coll Cardiol 67:1062-9

Showing the most recent 10 out of 19 publications