A pediatric component the Case Western Reserve University ACTU is proposed. The component will append to a highly successful adult ACTU (1st or 2nd quartile), which will provide the infrastructure to enable efficient enrollment of children at low additional cost. Though no funding has been available for pediatric protocols in the past, three patients have been successfully entered and maintained on pediatric trials. The rapidly expanding population of HIV-infected children in Cleveland ensures future candidates for enrollment. Subjects will be drawn from patients referred by community pediatricians and obstetricians to the Special Immunology Unit, the multi-disciplinary AIDS specialty clinic at University Hospitals of Cleveland. In addition, referrals will be made from two large HIV screening programs for urban minority pregnant women; both of these screening programs are administered by the pediatric component director, insuring expeditious referral. The total predicated referrals from these programs will equal 6 children with confirmed infection, and 25-48 seropositive maternal-infant pairs over the first twelve months, enabling enrollment of a minimum of six patients the first year, and 12/yr by the end of the funding period.

Project Start
1998-01-01
Project End
1998-12-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
11
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Chang, J Judy; Woods, Matt; Lindsay, Robert J et al. (2013) Higher expression of several interferon-stimulated genes in HIV-1-infected females after adjusting for the level of viral replication. J Infect Dis 208:830-8
Kyeyune, Fred; Nankya, Immaculate; Metha, Samar et al. (2013) Treatment failure and drug resistance is more frequent in HIV-1 subtype D versus subtype A-infected Ugandans over a 10-year study period. AIDS 27:1899-909
Imamichi, Hiromi; Degray, Gerald; Asmuth, David M et al. (2011) HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy. AIDS 25:159-64
Anthony, D D; Umbleja, T; Aberg, J A et al. (2011) Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals. Vaccine 29:3558-63
Tebit, Denis M; Lobritz, Michael; Lalonde, Matthew et al. (2010) Divergent evolution in reverse transcriptase (RT) of HIV-1 group O and M lineages: impact on structure, fitness, and sensitivity to nonnucleoside RT inhibitors. J Virol 84:9817-30
Lok, Judith J; Bosch, Ronald J; Benson, Constance A et al. (2010) Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection. AIDS 24:1867-76
Kalayjian, Robert C (2010) The treatment of HIV-associated nephropathy. Adv Chronic Kidney Dis 17:59-71
Winham, Stacey J; Slater, Andrew J; Motsinger-Reif, Alison A (2010) A comparison of internal validation techniques for multifactor dimensionality reduction. BMC Bioinformatics 11:394
Lassen, Kara G; Lobritz, Michael A; Bailey, Justin R et al. (2009) Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics. PLoS Pathog 5:e1000377
Robbins, Gregory K; Spritzler, John G; Chan, Ellen S et al. (2009) Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin Infect Dis 48:350-61

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