Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Singh, I R; Crowley, R A; Brown, P O (1997) High-resolution functional mapping of a cloned gene by genetic footprinting. Proc Natl Acad Sci U S A 94:1304-9
Roe, T; Chow, S A; Brown, P O (1997) 3'-end processing and kinetics of 5'-end joining during retroviral integration in vivo. J Virol 71:1334-40
Leavitt, A D; Robles, G; Alesandro, N et al. (1996) Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. J Virol 70:721-8
Lee, S I; Umen, J G; Varmus, H E (1995) A genetic screen identifies cellular factors involved in retroviral -1 frameshifting. Proc Natl Acad Sci U S A 92:6587-91
Dotan, I; Scottoline, B P; Heuer, T S et al. (1995) Characterization of recombinant murine leukemia virus integrase. J Virol 69:456-68
Ellison, V; Gerton, J; Vincent, K A et al. (1995) An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer. J Biol Chem 270:3320-6
Chow, S A; Brown, P O (1994) Juxtaposition of two viral DNA ends in a bimolecular disintegration reaction mediated by multimers of human immunodeficiency virus type 1 or murine leukemia virus integrase. J Virol 68:7869-78
Tuohy, T M; Li, Z; Atkins, J F et al. (1994) A functional mutant of tRNA(2Arg) with ten extra nucleotides in its TFC arm. J Mol Biol 235:1369-76
Chow, S A; Brown, P O (1994) Substrate features important for recognition and catalysis by human immunodeficiency virus type 1 integrase identified by using novel DNA substrates. J Virol 68:3896-907
Vincent, K A; Ellison, V; Chow, S A et al. (1993) Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations. J Virol 67:425-37

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