The Brooklyn WINS site is one of six clinical WIHS sites that together form the largest ongoing study of HIV infection in women in the US. he WIHS in general, and the SUNY Brooklyn site in particular, have demonstrated their ability to recruit, retain and report on a hard-to-reach population - poor, minority women of color- but a population that disproportionately constitutes the cohort of HIV infected people in this country. The Brooklyn WIHS site's retention rate, the highest among all of the WIHS sites, is 93.0% among the HIV- seropositives and 90.0% among the HIV-seronegatives. Our protocol compliance rates are above the WIHS-wide average in practically all study measures including data accuracy, specimen collection and colposcopy. In addition, we have contributed rapidly and disproportionately to most WIHS substudies. We plan to enroll a total of 441 women (306 HIV-seropositive, 135 HIV-seronegative) Brooklyn participants into WIHS IV. During WIHS IV, we will maintain or improve retention and protocol compliance rates, and continue to contribute to WIHS substudies. We have established an infrastructure that should assure success in implementing the protocols for WIHS IV. In collaboration with our colleagues at the other five WIHS sites and WDMAC, we are well-positioned to undertake the research agenda described in Part A of this application, an agenda which can substantively contribute to an understanding of HIV infection in women in the era of effective therapy. The SUNY Brooklyn WIHS investigators will contribute to the entire WIHS IV Science Agenda, with particular focus in the areas of neurocognition and behavioral science, cardiovascular and gynecological issues, including HPV infections. To position ourselves to best contribute to the success of WIHS IV we have initiated collaborations with external investigators, and have recruited new co-investigators with particular expertise in the areas of interest in the new proposal. The scientific insights and energies of the many collaborators at this and other sites will allow the WIHS to continue to be a resource capable of rapidly responding to advancing scientific knowledge in the field. Lay Language Summary: The Brooklyn WIHS site is one of six clinical WIHS sites that together form the largest ongoing epidemiologic study of HIV infection in women in the US. The contribution of Brooklyn investigators and field staff will enable the WIHS to achieve its logistic and scientific goals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI031834-20
Application #
8210829
Study Section
Special Emphasis Panel (ZAI1-LW-A (S1))
Program Officer
Roe, Joanad'Arc C
Project Start
1992-03-01
Project End
2012-12-31
Budget Start
2012-01-01
Budget End
2012-12-31
Support Year
20
Fiscal Year
2012
Total Cost
$3,090,109
Indirect Cost
$1,047,159
Name
Suny Downstate Medical Center
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
040796328
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Ghosh, Mimi; Daniels, Jason; Pyra, Maria et al. (2018) Impact of chronic sexual abuse and depression on inflammation and wound healing in the female reproductive tract of HIV-uninfected and HIV-infected women. PLoS One 13:e0198412
Rice, Whitney S; Logie, Carmen H; Napoles, Tessa M et al. (2018) Perceptions of intersectional stigma among diverse women living with HIV in the United States. Soc Sci Med 208:9-17
Kelso-Chichetto, N E; Okafor, C N; Cook, R L et al. (2018) Association Between Depressive Symptom Patterns and Clinical Profiles Among Persons Living with HIV. AIDS Behav 22:1411-1422
Adams, Leah M; Wilson, Tracey E; Merenstein, Daniel et al. (2018) Using the Center for Epidemiologic Studies Depression Scale to assess depression in women with HIV and women at risk for HIV: Are somatic items invariant? Psychol Assess 30:97-105
Galárraga, Omar; Rana, Aadia; Rahman, Momotazur et al. (2018) The effect of unstable housing on HIV treatment biomarkers: An instrumental variables approach. Soc Sci Med 214:70-82
Enkhmaa, Byambaa; Anuurad, Erdembileg; Zhang, Wei et al. (2018) Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study. J Lipid Res 59:1967-1976
Rubin, Leah H; Benning, Lorie; Keating, Sheila M et al. (2018) Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study. J Neurovirol 24:41-51
Belenky, Nadya; Pence, Brian W; Cole, Stephen R et al. (2018) Associations Between Medicare Part D and Out-of-Pocket Spending, HIV Viral Load, Adherence, and ADAP Use in Dual Eligibles With HIV. Med Care 56:47-53
Ascher, Simon B; Scherzer, Rebecca; Estrella, Michelle M et al. (2018) Association of Urinary Biomarkers of Kidney Injury with Estimated GFR Decline in HIV-Infected Individuals following Tenofovir Disoproxil Fumarate Initiation. Clin J Am Soc Nephrol 13:1321-1329
Hanna, David B; Moon, Jee-Young; Haberlen, Sabina A et al. (2018) Carotid artery atherosclerosis is associated with mortality in HIV-positive women and men. AIDS 32:2393-2403

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