The Connie Wofsy Women's HIV Study, the Northern California site of the Women's Interagency HIV Study (WIHS), a multisite cohort study is focused on the clinical, laboratory and psychosocial aspects of HIV infection in women. In the first four years, an organized infrastructure was created and interview, examination, and specimen data collected. Initial recruitment at this site included 336 HIV+ and 91 HIV-women who are well matched in terms of age, race, and education. The cohort is very diverse in terms of risk factors for acquisition of HIV infection, race, and age and by these characteristics are highly representative of women living with AIDS in the San Francisco Bay Area. Analysis of baseline data is well underway; to date, 21 abstract presentations and one published report have been completed. This WIHS II proposal includes multisite core studies and site-specific substudies. The core protocol tests specific hypotheses and creates a repository of interview data and specimens that are available for current and future substudies. These hypotheses take into consideration advances in understanding the pathogenesis and treatment of HIV infection.
Core aims and objectives include investigations of 1) HIV disease progression, 2) emergence of resistance to antiretroviral drugs, 3) the natural history of genital tract neoplasia and HPV infection, 4) expression of HIV in the lower genital tract, 5) the association between concurrent conditions and HIV disease progression, 6) malignancies and related infections, 7) the oral cavity, 8) HIV seroconversion, and 9) behavioral characteristics. The proposed research designs and methods are both a continuation of selected WIHS I activities (e.g. semiannual core follow-up visits), as well as studies designed to answer new research questions (e.g. laboratory testing for evidence of nucleoside and Indinavir resistance). The overall structure of the WIHS is ideal for the support of nested studies that utilize the extensive clinical database and specimen repository.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01AI034989-09S1
Application #
6684282
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Williams, Carolyn F
Project Start
1993-08-01
Project End
2003-02-28
Budget Start
2001-12-01
Budget End
2003-02-28
Support Year
9
Fiscal Year
2003
Total Cost
$754,635
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Gradissimo, Ana; Lam, Jessica; Attonito, John D et al. (2018) Methylation of High-Risk Human Papillomavirus Genomes Are Associated with Cervical Precancer in HIV-Positive Women. Cancer Epidemiol Biomarkers Prev 27:1407-1415
Mills, Jon C; Pence, Brian W; Todd, Jonathan V et al. (2018) Cumulative Burden of Depression and All-Cause Mortality in Women Living With Human Immunodeficiency Virus. Clin Infect Dis 67:1575-1581
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Kimura, Takayuki; Kobiyama, Kouji; Winkels, Holger et al. (2018) Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B. Circulation 138:1130-1143
Sharma, Anjali; Hoover, Donald R; Shi, Qiuhu et al. (2018) Longitudinal study of falls among HIV-infected and uninfected women: the role of cognition. Antivir Ther 23:179-190
Cook, Judith A; Burke-Miller, Jane K; Steigman, Pamela J et al. (2018) Prevalence, Comorbidity, and Correlates of Psychiatric and Substance Use Disorders and Associations with HIV Risk Behaviors in a Multisite Cohort of Women Living with HIV. AIDS Behav 22:3141-3154
Tamraz, Bani; Huang, Yong; French, Audrey L et al. (2018) A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair. Clin Pharmacol Ther 104:949-956
Zhang, Yuehan; Wilson, Tracey E; Adedimeji, Adebola et al. (2018) The Impact of Substance Use on Adherence to Antiretroviral Therapy Among HIV-Infected Women in the United States. AIDS Behav 22:896-908
Buchanan, Ashley L; Hudgens, Michael G; Cole, Stephen R et al. (2018) Generalizing Evidence from Randomized Trials using Inverse Probability of Sampling Weights. J R Stat Soc Ser A Stat Soc 181:1193-1209

Showing the most recent 10 out of 604 publications