Since the inception of WINS, the Bronx/Manhattan site has demonstrated both scientific and operational leadership nationally, and has provided the most data, with the largest retained cohort and the greatest participation in substudies. Dr. Anastos, the Bronx/Manhattan PI, has led the WIHS investigations of natural and treated history both before and after the introduction of HAART. In WIHS III the Bronx team has added to these accomplishments by broadening its scientific focus and markedly increasing its scientific productivity. This was achieved through development of a data analysis team, enhancement of our expertise in metabolic conditions of interest, the addition of a Co-PI with expertise in substance use and hepatitis C, continued support and flexibility for investigations of pathogenesis, and active management of data analysis and manuscript development. In WIHS III the Bronx has produced more papers than any other site in disease proa volume, completeness and quality;to develop further our local team's scientific productivity;to provide continued leadership in WIHS scientifically;and to develop further international collaborations in which WIHS can contribute to understanding of important parameters of the international epidemic in women. ????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035004-19
Application #
8212271
Study Section
Special Emphasis Panel (ZAI1-LW-A (S1))
Program Officer
Roe, Joanad'Arc C
Project Start
1993-08-01
Project End
2012-12-31
Budget Start
2012-01-01
Budget End
2012-12-31
Support Year
19
Fiscal Year
2012
Total Cost
$3,198,087
Indirect Cost
$593,523
Name
Montefiore Medical Center (Bronx, NY)
Department
Type
DUNS #
041581026
City
New York
State
NY
Country
United States
Zip Code
10467
Scherzer, Rebecca; Bacchetti, Peter; Messerlian, Geralyn et al. (2015) Impact of CD4+ lymphocytes and HIV infection on Anti-Müllerian Hormone levels in a large cohort of HIV-infected and HIV-uninfected women. Am J Reprod Immunol 73:273-84
Kuniholm, Mark H; Hanna, David B; Landay, Alan L et al. (2015) Soluble CD163 is associated with noninvasive measures of liver fibrosis in hepatitis C virus- and hepatitis C virus/human immunodeficiency virus-infected women. Hepatology 61:734-5
Adedimeji, Adebola A; Hoover, Donald R; Shi, Qiuhu et al. (2015) Sexual Behavior and Risk Practices of HIV Positive and HIV Negative Rwandan Women. AIDS Behav 19:1366-78
Aka, Peter V; Kuniholm, Mark H; Pfeiffer, Ruth M et al. (2014) Association of the IFNL4-?G Allele With Impaired Spontaneous Clearance of Hepatitis C Virus. J Infect Dis 209:350-4
Pyra, Maria; Weber, Kathleen; Wilson, Tracey E et al. (2014) Sexual minority status and violence among HIV infected and at-risk women. J Gen Intern Med 29:1131-8
Sirotin, Nicole; Hoover, Donald R; Shi, Qiuhu et al. (2014) Food insecurity with hunger is associated with obesity among HIV-infected and at risk women in Bronx, NY. PLoS One 9:e105957
Weber, Stefanie; Weiser, Barbara; Kemal, Kimdar S et al. (2014) Epigenetic analysis of HIV-1 proviral genomes from infected individuals: predominance of unmethylated CpG's. Virology 449:181-9
Massad, L Stewart; Pierce, Christopher B; Minkoff, Howard et al. (2014) Long-term cumulative incidence of cervical intraepithelial neoplasia grade 3 or worse after abnormal cytology: impact of HIV infection. Int J Cancer 134:1854-61
Massad, L Stewart; Xie, Xianhong; Burk, Robert et al. (2014) Long-term cumulative detection of human papillomavirus among HIV seropositive women. AIDS 28:2601-8
Benning, Lorie; Golub, Elizabeth T; Anastos, Kathryn et al. (2014) Comparison of lower genital tract microbiota in HIV-infected and uninfected women from Rwanda and the US. PLoS One 9:e96844

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