2011 was a transformative year in HIV research, providing evidence and raising hope that the HIV epidemic globally can potentially be not only controlled but also effectively aborted in our lifetime through both prevention and cure. Effective primary prevention through microbicides, pre-exposure prophylaxis and treatment of persons living with HIV (PLWH) seems within our reach. Equally important, basic science advances suggest that cure is possible through activation and/or elimination of HIV proviral DNA from host cells. We propose a WIHS scientific agenda that informs these possible routes to defeating HIV, through investigations of genital tract innate immune factors protecting against HIV-infection;identification of epigenetic changes in the provirus that may define a target for cure;and elucidating cell-to-cell viral transfer. We will continue to use WIHS's robust database to inform effective treatment for women and persons of African descent. Of the 34.0 million PLWH globally more than half of are women, and more than 75% are of African ancestry;nearly all studies of the efficacy of antiretroviral therapy (ART) are in men of European descent. Thus, epidemiologic and translational investigation of population- based effectiveness of ART in WIHS, which is 100% women and >60% of African descent, will provide critical information for patients and providers both in the US and globally. Further, with 18 years of prospective data collection the WIHS is able to investigate clinical manifestations in aging populations, including studies of changes in the genital tract with reproductive aging. The Bronx WIHS has provided both operational excellence and scientific leadership nationally since WIHS's inception in 1993. In WIHS V we will continue to lead the WIHS-wide investigations in HPV and cervical neoplasia;cardiovascular disease and inflammation;genital tract mucosal immunology and virology;immunogenetics;HIV virology;musculoskeletal manifestations of HIV disease;and host characteristics influencing population based effectiveness of ART. We will also continue our excellent operational performance in providing high volume, complete, high quality data both for the WIHS core activities, and all substudies.
With the tools to end the epidemic potentially in the view, it is imperative both to monitor the effectiveness of ART in a diverse population, and also to continue investigations of pathogenesis and the correlates of protection from HIV infection. WIHS provides a flexible and effective platform for prospective investigations for understanding of HIV infection and its treatment.
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|Burke-Miller, Jane K; Weber, Kathleen; Cohn, Susan E et al. (2017) Measurement of Neighborhood Context in an Urban Cohort of HIV-infected or at risk Low-Income Women. J Poverty 21:80-96|
|Price, Jennifer C; Ma, Yifei; Scherzer, Rebecca et al. (2017) Human immunodeficiency virus-infected and uninfected adults with non-genotype 3 hepatitis C virus have less hepatic steatosis than adults with neither infection. Hepatology 65:853-863|
|Reid, Michael; Ma, Yifei; Scherzer, Rebecca et al. (2017) Higher CD163 levels are associated with insulin resistance in hepatitis C virus-infected and HIV-infected adults. AIDS 31:385-393|
|McFarlane, Samy I; Mielke, Michelle M; Uglialoro, Anthony et al. (2017) Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study. J Neurol Neurophysiol 8:|
|Haddad, Lisa B; Wall, Kristin M; Mehta, C Christina et al. (2017) Trends of and factors associated with live-birth and abortion rates among HIV-positive and HIV-negative women. Am J Obstet Gynecol 216:71.e1-71.e16|
|Kuniholm, Mark H; Liang, Hua; Anastos, Kathryn et al. (2017) Association of a 3' Untranslated Region Polymorphism in PCSK9 with HIV Viral Load and CD4+ Levels in HIV/Hepatitis C Virus Co-Infected Women. AIDS :|
|Nabi, Rafiq; Moldoveanu, Zina; Wei, Qing et al. (2017) Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy. PLoS One 12:e0180245|
|French, Audrey L; Martin, Jonathan W; Evans, Charlesnika T et al. (2017) Macrophage Activation and the Tumor Necrosis Factor Cascade in Hepatitis C Disease Progression Among HIV-Infected Women Participating in the Women's Interagency HIV Study. J Acquir Immune Defic Syndr 76:438-444|
|Butterfield, Tiffany R; Hanna, David B; Kaplan, Robert C et al. (2017) Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease. AIDS 31:199-205|
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