The Chicago component of the Multicenter AIDS Cohort Study (MACS) is composed of a representative sample of men infected with HIV or at risk for such infection. We are in the third decade of research with three clinical sites located at the Howard Brown Health Center, the Northwestern University HIV/AIDS Clinic and the CORE Center of Cook County Hospital. The collected data and specimens from the participants have provided and will continue to provide detailed information about the role of host and environmental factors in HIV disease. During the next funding cycle (2009 to 2014), we will support studies of the natural and treated history of HIV infection and HIV-associated disease in the era of highly active antiretroviral therapy (HAART) through standardized and detailed data and specimen collection at 6-month intervals to characterize exposures and risk factors. We will support ongoing MACS-wide research projects and initiate new projects on: behaviors enhancing transmission of HIV-1;the responses, effects, and predictors of response to HAART including the impact of illicit drug use;the effects of aging on the clinical course of HIV, HIV therapy, and response to HIV therapy;the host environment interaction between host genetics and HIV and other exposures;and the impact of aging, HAART and/or HIV infection on end-organ disease, cancer (both AIDS-related and non-related) upon long-term survival of infected men. We will contribute to each of the aims through scientific leadership, development and implementation of the overall MACS scientific agenda, retention and maintenance of the cohort and development of a state of the art facility using novel technology to conduct MACS-wide investigations of host genetics.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-EB-A (J1))
Program Officer
Roe, Joanad'Arc C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Hart, Trevor A; Mustanski, Brian; Ryan, Daniel T et al. (2015) Depression and sexual dysfunction among HIV-positive and HIV-negative men who have sex with men: mediation by use of antidepressants and recreational stimulants. Arch Sex Behav 44:399-409
Becker, James T; Martinson, Jeremy J; Penugonda, Sudhir et al. (2015) No association between Apo?4 alleles, HIV infection, age, neuropsychological outcome, or death. J Neurovirol 21:24-31
Viswanathan, Shilpa; Detels, Roger; Mehta, Shruti H et al. (2015) Level of adherence and HIV RNA suppression in the current era of highly active antiretroviral therapy (HAART). AIDS Behav 19:601-11
Becker, James T; Kingsley, Lawrence A; Molsberry, Samantha et al. (2015) Cohort Profile: Recruitment cohorts in the neuropsychological substudy of the Multicenter AIDS Cohort Study. Int J Epidemiol 44:1506-16
Bashirova, Arman A; Martin-Gayo, Enrique; Jones, Des C et al. (2014) LILRB2 interaction with HLA class I correlates with control of HIV-1 infection. PLoS Genet 10:e1004196
Cousins, Matthew M; Konikoff, Jacob; Sabin, Devin et al. (2014) A comparison of two measures of HIV diversity in multi-assay algorithms for HIV incidence estimation. PLoS One 9:e101043
Mata, Mariana M; Iwema, Joyce R; Dell, Shanna et al. (2014) Comparison of antibodies that mediate HIV type 1 gp120 antibody-dependent cell-mediated cytotoxicity in asymptomatic HIV type 1-positive men and women. AIDS Res Hum Retroviruses 30:50-7
Vendrame, Elena; Hussain, Shehnaz K; Breen, Elizabeth Crabb et al. (2014) Serum levels of cytokines and biomarkers for inflammation and immune activation, and HIV-associated non-Hodgkin B-cell lymphoma risk. Cancer Epidemiol Biomarkers Prev 23:343-9
Cousins, Matthew M; Konikoff, Jacob; Laeyendecker, Oliver et al. (2014) HIV diversity as a biomarker for HIV incidence estimation: including a high-resolution melting diversity assay in a multiassay algorithm. J Clin Microbiol 52:115-21
Chang, Po-Yin; Detels, Roger; Martínez-Maza, Otoniel et al. (2014) Comment on "characteristics of B-cell lymphomas in HIV/HCV-coinfected patients during the combined antiretroviral therapy era: an ANRS CO16 LYMPHOVIR cohort study". J Acquir Immune Defic Syndr 67:e84-6

Showing the most recent 10 out of 280 publications