This is a proposal to continue to document the natural history of untreated and treated HIV infection in: 1) a group of 1637 men-who-have-sex-with-men (MSM) originally recruited in 1984-5; and 2) a group of 363 young Latino and African-American MSM recruited in 2002-3. The men are followed at three clinics (UCLA-Wilshire, UCLA/Harbor Research and Education Institute, and the Gay and Lesbian Center) with an extensive questionnaire eliciting behavioral, medical, and psychosocial information; physical examination; blood collection for concurrent evaluation of HIV status (HIV-negatives), viral load (HIV-positives), levels of T cells subsets, activation markers, and lipids; and assessment of HBV and HCV markers. Equal aliquots of serum, plasma, and cells are stored at the UCLA and the National Repository. The outcome status of 91% of the 1984-5 cohort is known, attributable in part to the outstanding commitment of the staff, most of whom have been with the UCLA center for more than ten years, and several for 20 years. The 2002-3 cohort members are in the process of completing their first follow-up visit. The UCLA site has demonstrated its scientific leadership through leadership roles in the MACS Executive Committee (Detels), chairmanship of the Malignancy (Martinez), and Neuropsychological (Miller) working groups, and leadership roles in flow cytometry (Jamieson), viral testing procedures (Young), and studies of resistance to HIV (Detels). UCLA investigators have been the lead authors on 65 MACS-wide and UCLA center-specific scientific publications since 1998. The objectives of the UCLA MACS Clinical Center are to: 1. Maintain the cohort of 2000 men recruited in 1984-85 and 2002-3 through 2009; 2. Collect specific clinical, behavioral, and psychosocial data and laboratory specimens to meet the scientific objectives of the MACS (see Part A submitted by the CAMACS); 3. Contribute scientific leadership for the overall MACS and extend scientific knowledge about the natural history of untreated and treated HIV disease; and, 4. Promote involvement in the MACS by qualified investigators at UCLA and other institutions. With the assistance of its Community Advisory Board and its outstanding staff, the UCLA Center of the MACS is committed to maintaining the same level of commitment, leadership and follow-up of the cohort through 2009.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI035040-16
Application #
7433883
Study Section
Special Emphasis Panel (ZAI1-EB-A (J1))
Program Officer
Roe, Joanad'Arc C
Project Start
1993-04-01
Project End
2009-04-24
Budget Start
2008-04-01
Budget End
2009-04-24
Support Year
16
Fiscal Year
2008
Total Cost
$3,972,360
Indirect Cost
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Tipton, Laura; Cuenco, Karen T; Huang, Laurence et al. (2018) Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData Min 11:12
Epeldegui, Marta; Magpantay, Larry; Guo, Yu et al. (2018) A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma. AIDS 32:945-954
Kelso-Chichetto, N E; Okafor, C N; Cook, R L et al. (2018) Association Between Depressive Symptom Patterns and Clinical Profiles Among Persons Living with HIV. AIDS Behav 22:1411-1422
Molsberry, Samantha A; Cheng, Yu; Kingsley, Lawrence et al. (2018) Neuropsychological phenotypes among men with and without HIV disease in the multicenter AIDS cohort study. AIDS 32:1679-1688
Lake, Jordan E; Li, Xiuhong; Palella Jr, Frank J et al. (2018) Metabolic health across the BMI spectrum in HIV-infected and HIV-uninfected men. AIDS 32:49-57
Ascher, Simon B; Scherzer, Rebecca; Estrella, Michelle M et al. (2018) Association of Urinary Biomarkers of Kidney Injury with Estimated GFR Decline in HIV-Infected Individuals following Tenofovir Disoproxil Fumarate Initiation. Clin J Am Soc Nephrol 13:1321-1329
Hanna, David B; Moon, Jee-Young; Haberlen, Sabina A et al. (2018) Carotid artery atherosclerosis is associated with mortality in HIV-positive women and men. AIDS 32:2393-2403
Levine, Andrew J; Martin, Eileen; Munro, Cynthia A et al. (2018) Intraindividual variability in neurocognitive performance: No influence due to HIV status or self-reported effort. J Clin Exp Neuropsychol 40:1044-1049
Robbins, Hilary A; Wiley, Dorothy J; Ho, Ken et al. (2018) Patterns of repeated anal cytology results among HIV-positive and HIV-negative men who have sex with men. Papillomavirus Res 5:143-149
Abraham, Alison G; Zhang, Long; Calkins, Keri et al. (2018) Vitamin D status and immune function reconstitution in HIV-infected men initiating therapy. AIDS 32:1069-1076

Showing the most recent 10 out of 526 publications