The epidemiology of HIV in the Asia-Pacific region reflects local drivers of infection (e.g., male-to-male sex, injection drug use), key co-infections that impact treatment outcomes (e.g., hepatitis B and 0, tuberculosis), and a range of treatment access and national resource levels. In addition, emerging evidence suggests that the pharmacology and toxicity of antiretroviral drugs in Asian populations are significantly different from Caucasian patients, which could impact long-term treatment tolerability and success. The overall goal of the Asia-Pacific HIV Research Collaboration is to evaluate the impact of HIV disease, co-infections, and ART management on clinical outcomes in the region. Research builds on existing scientific capacity for both broad regional and multiregional analyses and targeted studies on specific outcomes of interest within at-risk populations. The core research relies upon data from the Asia-Pacific HIV Observational Database (APHOD), comprised of the TREAT Asia HIV Observational Database (TAHOD) and the Australian HIV Observational Database (AHOD). Core research also includes the TREAT Asia Pediatric HIV Observational Database (TApHOD). These three established cohorts include data from 60 clinical centers at 54 institutions in 14 South, Southeast and East Asian countries and Australia. A separate collaboration with the National Center for AIDS/STD Control and Prevention (NCAIDS), China CDC, will conduct epidemiologic studies using the China National ART Database, a national surveillance program. Data collection will expand current studies in several innovative areas, with specific aims looking at factors driving the epidemic, as well as the response to ART, impact of co-infections, toxicity of first- and second-line regimens, cancer risk, chronic AIDS- and non-AIDS-related events and outcomes, drug resistance patterns, and cultural and behavioral factors affecting patient management and outcomes. The inclusion of research sites from a wide variety of geographic and socio-economic settings will continue to strengthen the existing adult and pediatric research networks. Successful implementation of these studies will build up an evidence base to inform HIV clinical management practices and programs, advise national and regional treatment guidelines, and add to global understanding of the epidemiology of HIV.

Public Health Relevance

Published findings on short- and long-term HIV treatment outcomes will lead to more effective, evidence- based clinical management practices for HIV-infected adults and children in the Asia-Pacific region. Identifying risk factors for cancer will help guide future prevention and screening efforts. Participating sites will gain capacity to expand local and regional research activities to better understand the epidemiology of HIV.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Project--Cooperative Agreements (U01)
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Application #
Study Section
Special Emphasis Panel (ZAI1-BB-A (M2))
Program Officer
Zimand, Lori B
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Foundation for AIDS Research
New York
United States
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Carlucci, James G; Blevins Peratikos, Meridith; Kipp, Aaron M et al. (2017) Tuberculosis Treatment Outcomes Among HIV/TB-Coinfected Children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) Network. J Acquir Immune Defic Syndr 75:156-163
Gray, Richard T; Watson, Jo; Cogle, Aaron J et al. (2017) Funding antiretroviral treatment for HIV-positive temporary residents in Australia prevents transmission and is inexpensive. Sex Health :
Clouse, Kate; Blevins, Meridith; Lindegren, Mary Lou et al. (2017) Low implementation of Xpert MTB/RIF among HIV/TB co-infected adults in the International epidemiologic Databases to Evaluate AIDS (IeDEA) program. PLoS One 12:e0171384
De La Mata, Nicole L; Ahn, Mi-Young; Kumarasamy, Nagalingeswaran et al. (2017) A pseudo-random patient sampling method evaluated. J Clin Epidemiol 81:129-139
Anand, Tarandeep; Nitpolprasert, Chattiya; Trachunthong, Deondara et al. (2017) A novel Online-to-Offline (O2O) model for pre-exposure prophylaxis and HIV testing scale up. J Int AIDS Soc 20:21326
Yen, Yung-Feng; Chen, Marcelo; Jen, Ian et al. (2017) Association of HIV and Opportunistic Infections With Incident Stroke: A Nationwide Population-Based Cohort Study in Taiwan. J Acquir Immune Defic Syndr 74:117-125
Bijker, Rimke; Jiamsakul, Awachana; Kityo, Cissy et al. (2017) Adherence to antiretroviral therapy for HIV in sub-Saharan Africa and Asia: a comparative analysis of two regional cohorts. J Int AIDS Soc 20:21218
Montaner, Julio; Rojo, Pablo; Anand, Tarandeep et al. (2017) Highlights of the International Congress on Drug Therapy in HIV Infection, 23-26 October 2016, Glasgow, UK. J Virus Erad 3:97-100
Brown, Steven A; Abbas, Salma; Davies, Mary-Ann et al. (2017) Brief Report: Pediatric Cancer Burden and Treatment Resources Within the Pediatric IeDEA Consortium. J Acquir Immune Defic Syndr 76:60-64
Sudjaritruk, Tavitiya; Aurpibul, Linda; Ly, Penh Sun et al. (2017) Incidence of Postsuppression Virologic Rebound in Perinatally HIV-Infected Asian Adolescents on Stable Combination Antiretroviral Therapy. J Adolesc Health 61:91-98

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