The Caribbean, Central and South America network for HIV epidemiology (CCASAnet) is an established and productive network that is responsive to scientific opportunities arising in the region and across International Epidemiologic Databases to Evaluate AIDS (leDEA) regions worldwide. This successful collaboration, created during the first leDEA funding cycle, has resulted in the productive enrichment and merging of human and technological resources from HIV clinical care and research sites in Port-au-Prince, Mexico City, Tegucigalpa, Lima, Rio de Janeiro, Buenos Aires, and Santiago, and the Vanderbilt Data Coordinating Center (DCC). The Vanderbilt DCC will continue to effectively harmonize and analyze complex databases and manage the CCASAnet 2.0 consortium. The project will conduct and facilitate research using the shared data repository to answer questions that cannot be answered by any single source. The clinical outcomes and complications related to HIV infection and antiretroviral therapy in the region will be evaluated. Studies are proposed to determine the impact of infections other than HIV, particularly tuberculosis, hepatitis, and human papillomavirus. Factors uniquely related to adolescents and young adults with HIV will be addressed across the region. Innovative biostatistical and informatics methods will be developed and applied. Biologic specimen repositories will be established that will facilitate future translational research. Programs for mentoring and education to enhance clinical research and data management capabilities at CCASAnet sites, promote junior researchers, and catalyze ongoing growth of scientific leadership in the region will be implemented. By these activities, CCASAnet 2.0 will help advance both the science of HIV epidemiology, and the information science that underpins international research collaboration.

Public Health Relevance

The project seeks to articulate contemporary research questions that are important to the dynamics of the global HIV epidemic and other infectious diseases within CCASAnet consortium countries. The proposed research will increase the understanding of similarities and differences in patterns of HIV care and disease outcomes in the Caribbean and Latin America, and will address issues that are also compelling in other regional settings

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AI069923-08
Application #
8510546
Study Section
Special Emphasis Panel (ZAI1-BB-A (M2))
Program Officer
Zimand, Lori B
Project Start
2006-06-15
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$2,488,424
Indirect Cost
$374,085
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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Cesar, Carina; Koethe, John R; Giganti, Mark J et al. (2016) Health outcomes among HIV-positive Latinos initiating antiretroviral therapy in North America versus Central and South America. J Int AIDS Soc 19:20684
Rachlis, Beth; Karwa, Rakhi; Chema, Celia et al. (2016) Targeted Spontaneous Reporting: Assessing Opportunities to Conduct Routine Pharmacovigilance for Antiretroviral Treatment on an International Scale. Drug Saf 39:959-76
Wolff, Marcelo; Shepherd, Bryan E; Cortés, Claudia et al. (2016) Clinical and Virologic Outcomes After Changes in First Antiretroviral Regimen at 7 Sites in the Caribbean, Central and South America Network. J Acquir Immune Defic Syndr 71:102-10
Althoff, Keri N; Rebeiro, Peter F; Hanna, David B et al. (2016) A picture is worth a thousand words: maps of HIV indicators to inform research, programs, and policy from NA-ACCORD and CCASAnet clinical cohorts. J Int AIDS Soc 19:20707
Coelho, Lara; Grinsztejn, Beatriz; Castilho, Jessica L et al. (2016) Mortality in HIV-infected women, heterosexual men, and men who have sex with men in Rio de Janeiro, Brazil: an observational cohort study. Lancet HIV 3:e490-8
De Boni, Raquel B; Shepherd, Bryan E; Grinsztejn, Beatriz et al. (2016) Substance Use and Adherence Among People Living with HIV/AIDS Receiving cART in Latin America. AIDS Behav 20:2692-2699
Diaz, Chanelle M; Segura, Eddy R; Luz, Paula M et al. (2016) Traditional and HIV-specific risk factors for cardiovascular morbidity and mortality among HIV-infected adults in Brazil: a retrospective cohort study. BMC Infect Dis 16:376
Blevins, Meridith; Wehbe, Firas H; Rebeiro, Peter F et al. (2016) Interactive Data Visualization for HIV Cohorts: Leveraging Data Exchange Standards to Share and Reuse Research Tools. PLoS One 11:e0151201
Charles, M Katherine; Lindegren, Mary Lou; Wester, C William et al. (2016) Implementation of Tuberculosis Intensive Case Finding, Isoniazid Preventive Therapy, and Infection Control ("Three I's") and HIV-Tuberculosis Service Integration in Lower Income Countries. PLoS One 11:e0153243

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