Asthma is one of the most common chronic illnesses and it disproportionately affects disadvantaged populations residing in urban areas. Mouse allergen exposure, in particular, appears to play a critical role in the urban asthma epidemic for several reasons: (1) Mus m 1, the major mouse allergen, is found in 95% of inner-city homes, and is found in 100-fold higher concentrations in inner-city homes than in suburban homes;(2) As many as 25-50% of children with asthma living in urban areas have evidence of IgE-sensitization to mouse, making them susceptible to mouse allergen-triggered asthma symptoms;and (3) Home mouse allergen exposure is associated with more symptoms days, more rescue medication use, and more asthma related health care use among IgE-sensitized children with asthma. Although these are compelling observations, demonstrating that a reduction of mouse allergen exposure results in Improved asthma health in mouse-sensitized children with asthma is critical for establishing a causal role for mouse allergen exposure. Preliminary evidence indicating that a mouse allergen-targeted environmental intervention (MA-EI) is efficacious in reducing settled dust Mus m 1 levels by >75% provides the final piece of background data to support the hypothesis that a MA-EI will reduce asthma morbidity in mouse-sensitized individuals with asthma. To test this hypothesis, we propose conducting a multi-center, randomized clinical trial of MA-EI at two major Northeastern US urban centers with high prevalence of asthma and mouse sensitization and high home Mus m 1 levels.
Aim 1 is: To determine the efficacy of this MA-IE to: (a) Reduce asthma symptoms and rescue medication use, (b) Reduce asthma-related health care utilization, and (c) Improve physiologic and inflammatory markers of asthma disease activity among mouse-sensitized children with asthma.
Aim 2 is: To evaluate mouse-specific IgG and IgE as biomarkers of allergen exposure and asthma clinical status. The findings from the clinical trial will lend critical insight into the impact of home mouse allergen exposure on urban populations with asthma, and directly inform public health strategies to reduce the inner-city asthma burden.
|Ahluwalia, Sharon K; Matsui, Elizabeth C (2018) Indoor Environmental Interventions for Furry Pet Allergens, Pest Allergens, and Mold: Looking to the Future. J Allergy Clin Immunol Pract 6:9-19|
|Gordon, Julian; Reboulet, Rachel; Gandhi, Prasanthi et al. (2018) Validation of a novel sampling technology for airborne allergens in low-income urban homes. Ann Allergy Asthma Immunol 120:96-97.e1|
|Wu, Tianshi David; Brigham, Emily P; Peng, Roger et al. (2018) Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. J Allergy Clin Immunol Pract 6:2157-2159.e5|
|Grant, Torie; Aloe, Charles; Perzanowski, Matthew et al. (2017) Mouse Sensitization and Exposure Are Associated with Asthma Severity in Urban Children. J Allergy Clin Immunol Pract 5:1008-1014.e1|
|Hughes, Helen K; Matsui, Elizabeth C; Tschudy, Megan M et al. (2017) Pediatric Asthma Health Disparities: Race, Hardship, Housing, and Asthma in a National Survey. Acad Pediatr 17:127-134|
|Matsui, Elizabeth C; Keet, Corinne A (2017) Weighing the evidence: Bias and confounding in epidemiologic studies in allergy/immunology. J Allergy Clin Immunol 139:448-450|
|Matsui, Elizabeth C; Perzanowski, Matthew; Peng, Roger D et al. (2017) Effect of an Integrated Pest Management Intervention on Asthma Symptoms Among Mouse-Sensitized Children and Adolescents With Asthma: A Randomized Clinical Trial. JAMA 317:1027-1036|
|Miller, Rachel L; Zhang, Hanjie; Jezioro, Jacqueline et al. (2017) Reduced mouse allergen is associated with epigenetic changes in regulatory genes, but not mouse sensitization, in asthmatic children. Environ Res 156:619-624|
|Sedaghat, Ahmad R; Matsui, Elizabeth C; Baxi, Sachin N et al. (2016) Mouse Sensitivity is an Independent Risk Factor for Rhinitis in Children with Asthma. J Allergy Clin Immunol Pract 4:82-8.e1|
|Kanchongkittiphon, Watcharoot; Gaffin, Jonathan M; Kopel, Lianne et al. (2016) Association of FEF25%-75% and bronchodilator reversibility with asthma control and asthma morbidity in inner-city children with asthma. Ann Allergy Asthma Immunol 117:97-9|
Showing the most recent 10 out of 25 publications