Our long-term research goal is to enhance the value of the Patient Reported Outcomes Measurement Information System (PROMIS) in clinical research in children. To bring the work of the first phase PROMIS pediatric item bank creation to fruition will entail demonstrating superior reliability, validity, and sensitivity to change of the PROMIS measures when compared to legacy items. Our objective is to demonstrate the content and construct validity of the PROMIS pediatric tool in important medical conditions of childhood that impair physical function and result in reduced health related quality of life (HRQOL): juvenile idiopathic arthritis (JIA), cerebral palsy (CP), and pediatric chronic pain syndromes. The PROMIS pediatric pain domain is recognized to need further development to add measurement of other facets of the pain experience to the current measure of pain impact. Given the centrality of pain to HRQOL, an important driver of this proposal is to enrich the PROMIS pediatric tool by developing and testing new pediatric pain item banks to address the large unmet need for adequate measurement of pain in children.
Our Specific Aims are thus: 1) to evaluate the validity and responsiveness of the PROMIS pediatric item banks with longitudinal assessments in children with JIA, CP, and chronic musculoskeletal pain. In each study population, we will assess content validity with key informant interviews, and analyze construct validity with co-administration of legacy scales and by test of responsiveness to change. A final product will be the determination of minimal important differences (MIDs) in PROMIS measures. And 2), to enhance PROMIS pediatric pain assessment with new item bank creation and testing. In recognition of the multiple facets of the pain experience, PROMIS pediatric pain items will be developed in the areas of pain intensity, pain quality, and pain behavior. Item creation will follow the established PROMIS process including qualitative item review and cognitive interviews with patients with chronic and recurrent painful conditions. Construct validity will be assessed by correlation with co-administered legacy scales. The expected outcome of the project is to foster use of PROMIS for improved PRO measurement in Pediatric Pain, Rheumatology and Rehabilitation Research.

Public Health Relevance

Medical interventions seek to improve the quality of life of patients, including their pain, physical functioning and emotional well-being. Patient reported outcomes measurement is critical to assessing the usefulness of any medical intervention. This proposal will test the validity and responsiveness to change of the PROMIS tool for assessment of health in children with Juvenile Idiopathic Arthritis, Cerebral Palsy, and Chronic Pain. The project also aims to improve assessment of pain in children by creating new PROMIS pain measures.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AR057940-04
Application #
8334396
Study Section
Special Emphasis Panel (ZRG1-RPHB-A (54))
Program Officer
Serrate-Sztein, Susana
Project Start
2009-09-30
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$596,036
Indirect Cost
$276,049
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Pilkonis, Paul A; Yu, Lan; Dodds, Nathan E et al. (2014) Validation of the depression item bank from the Patient-Reported Outcomes Measurement Information System (PROMIS) in a three-month observational study. J Psychiatr Res 56:112-9
Tucker, Carole A; Bevans, Katherine B; Teneralli, Rachel E et al. (2014) Self-reported pediatric measures of physical activity, sedentary behavior, and strength impact for PROMIS: conceptual framework. Pediatr Phys Ther 26:376-84
Fries, James F; Lingala, Bharathi; Siemons, Liseth et al. (2014) Extending the floor and the ceiling for assessment of physical function. Arthritis Rheumatol 66:1378-87
Junghaenel, Doerte U; Schneider, Stefan; Stone, Arthur A et al. (2014) Ecological validity and clinical utility of Patient-Reported Outcomes Measurement Information System (PROMIS®) instruments for detecting premenstrual symptoms of depression, anger, and fatigue. J Psychosom Res 76:300-6
Tucker, Carole A; Bevans, Katherine B; Teneralli, Rachel E et al. (2014) Self-reported pediatric measures of physical activity, sedentary behavior, and strength impact for PROMIS: item development. Pediatr Phys Ther 26:385-92
Buckner, Tyler W; Wang, Jichuan; DeWalt, Darren A et al. (2014) Patterns of symptoms and functional impairments in children with cancer. Pediatr Blood Cancer 61:1282-8
Menard, Johanna C; Hinds, Pamela S; Jacobs, Shana S et al. (2014) Feasibility and acceptability of the patient-reported outcomes measurement information system measures in children and adolescents in active cancer treatment and survivorship. Cancer Nurs 37:66-74
Lyon, Debra; McCain, Nancy; Elswick, R K et al. (2014) Biobehavioral examination of fatigue across populations: report from a P30 Center of Excellence. Nurs Outlook 62:322-31
Forrest, Christopher B; Bevans, Katherine B; Pratiwadi, Ramya et al. (2014) Development of the PROMIS ® pediatric global health (PGH-7) measure. Qual Life Res 23:1221-31
Selewski, David T; Collier, David N; MacHardy, Jackie et al. (2013) Promising insights into the health related quality of life for children with severe obesity. Health Qual Life Outcomes 11:29

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