Our vision is to represent the human musculoskeletal system, through the creation of data and models, with the realism needed to understand pathology and improve treatment. The human body is inherently multiscale. Diseases and injuries often affect tissues at the microstructural scale; small-scale pathology impacts biomechanics at larger scales, leading to whole-body movement compensations that oftentimes promote further injury or accelerate degeneration. Ultimately, a multiscale approach, describing the behavior of individual tissues, and the biomechanics of the whole body, is needed to elucidate the etiology of diseases, mechanisms of adaptation and best treatments. The overall goal of this proposal is to create a comprehensive multiscale neuromusculoskeletal model of the human lower extremity, which includes seamless connection between tissue and whole-body function during dynamic human activities and enables realistic investigations of musculoskeletal disease and treatment. While we will create and share models with broad applicability in biomechanics, our target is understanding the effects of knee osteoarthritis (OA) on patient function and optimizing treatment through total knee arthroplasty (TKA). OA is a serious degenerative joint disease and the leading cause of disability in the elderly. Moreover, OA is interrelated with many pressing health concerns, including obesity, cardiovascular disease (CVD), Alzheimer?s disease, dementia, and depression. Joint replacement remains the only effective treatment for advanced OA. Unfortunately, as many as 20-30% of total joint replacement patients report pain, require additional surgeries, and endure a poor movement-related quality of life. A tenet of our research is the use of human modeling and simulation to investigate the multiscale effects of OA on patients, and to improve the design and practice of joint replacement surgery.

Public Health Relevance

Diseases and injuries often affect tissues at the microstructural scale; small-scale pathology impacts biomechanics at larger scales, leading to whole-body movement compensations that oftentimes promote further injury or accelerate degeneration. Our overall goal is to create a comprehensive multiscale neuromusculoskeletal model of the human lower extremity, which includes seamless connection between tissue and whole-body function during dynamic human activities and enables realistic investigations of musculoskeletal disease and treatment. While we will create and share models with broad applicability in biomechanics, our target is understanding the effects of knee osteoarthritis on patient function, and optimizing treatment through total knee arthroplasty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01AR072989-01A1
Application #
9419491
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Kirilusha, Anthony G
Project Start
2018-09-07
Project End
2022-07-31
Budget Start
2018-09-07
Budget End
2019-07-31
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Denver
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
007431760
City
Denver
State
CO
Country
United States
Zip Code
80210