Osteoporosis is a major health issue in postmenopausal women. Our long-term goal is to develop a complementary and alternative medicine (CAM) intervention including dietary supplement (green tea polyphenols, GTP) for bone health. The overall objective of this U01 application is to find an optimal dose of GTP that would be employed to a long-term GTP supplementation clinical trial in postmenopausal osteopenic women. Our central hypothesis is that the GTP will improve bone health through increasing bone formation and decreasing bone resorption. There are 4 different projects involved in the proposed study: Project 1 - bone biomarker measurement in the serum samples;Project 2 -preclinical animal dose-response GTP study;Project 3 - demonstrate BMD measurement proficiency;and Project 4 - human dose-response study of GTP. The significance of this study is in its CAM approach to the mitigation of bone loss in postmenopausal women.

Public Health Relevance

Osteoporosis is a major health issue in postmenopausal women. Our long-term goal is to develop a complementary and alternative medicine (CAM) intervention including dietary supplement (green tea polyphenols, GTP) for bone health. The overall objective of this project is to find an optimal dose of GTP that would be employed to a long-term GTP supplementation clinical trial in postmenopausal osteopenic women. Our central hypothesis is that the GTP will improve bone health through increasing bone formation and decreasing bone resorption.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01AT006691-01A1
Application #
8291809
Study Section
Behavioral Medicine, Interventions and Outcomes Study Section (BMIO)
Program Officer
Khalsa, Partap Singh
Project Start
2012-09-30
Project End
2017-06-30
Budget Start
2012-09-30
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$337,924
Indirect Cost
$100,382
Name
Texas Tech University
Department
Pathology
Type
Schools of Medicine
DUNS #
609980727
City
Lubbock
State
TX
Country
United States
Zip Code
79430
Wang, Shu; Moustaid-Moussa, Naima; Chen, Lixia et al. (2014) Novel insights of dietary polyphenols and obesity. J Nutr Biochem 25:1-18