Osteoporosis is a major health issue in postmenopausal women. Our long-term goal is to develop a complementary and alternative medicine (CAM) intervention including dietary supplement (green tea polyphenols, GTP) for bone health. The overall objective of this U01 application is to find an optimal dose of GTP that would be employed to a long-term GTP supplementation clinical trial in postmenopausal osteopenic women. Our central hypothesis is that the GTP will improve bone health through increasing bone formation and decreasing bone resorption. There are 4 different projects involved in the proposed study: Project 1 - bone biomarker measurement in the serum samples;Project 2 -preclinical animal dose-response GTP study;Project 3 - demonstrate BMD measurement proficiency;and Project 4 - human dose-response study of GTP. The significance of this study is in its CAM approach to the mitigation of bone loss in postmenopausal women.

Public Health Relevance

Osteoporosis is a major health issue in postmenopausal women. Our long-term goal is to develop a complementary and alternative medicine (CAM) intervention including dietary supplement (green tea polyphenols, GTP) for bone health. The overall objective of this project is to find an optimal dose of GTP that would be employed to a long-term GTP supplementation clinical trial in postmenopausal osteopenic women. Our central hypothesis is that the GTP will improve bone health through increasing bone formation and decreasing bone resorption.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01AT006691-02
Application #
8544982
Study Section
Behavioral Medicine, Interventions and Outcomes Study Section (BMIO)
Program Officer
Khalsa, Partap Singh
Project Start
2012-09-30
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$332,123
Indirect Cost
$142,261
Name
Texas Tech University
Department
Pathology
Type
Schools of Medicine
DUNS #
609980727
City
Lubbock
State
TX
Country
United States
Zip Code
79430
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Shen, Chwan-Li; Kwun, In-Sook; Wang, Shu et al. (2013) Functions and mechanisms of green tea catechins in regulating bone remodeling. Curr Drug Targets 14:1619-30
Shen, Chwan-Li; Chyu, Ming-Chien; Wang, Jia-Sheng (2013) Tea and bone health: steps forward in translational nutrition. Am J Clin Nutr 98:1694S-1699S