The lARC Monographs on the Evaluation of Carcinogenic Risks to Humans represent an international expert-consensus approach to carcinogen hazard identification. The long-term objective is to critically review and evaluate the published scientific evidence on carcinogenic hazards to which humans are exposed. These include chemicals, complex mixtures, physical agents, biological agents, occupational exposures, and lifestyle factors. National and international health agencies use the lARC Monographs as a source of scientific information and as the scientific basis for their actions to prevent exposure to known, probable, and possible carcinogens. Each lARC Monograph contains a critical review of the published scientific literature and an evaluation of the weight of the evidence that an agent can increase the risk of cancer. Agents are selected for evaluation based on evidence of human exposure and some evidence of carcinogenicity. Agents can be re-evaluated if significant new data become available. The program also collaborates on scientific workshops to determine how to make the best use of contemporary studies to identify agents that play a role in cancer development and to understand their mechanisms. The Preamble to each volume of lARC Monographs describes the principles and procedures that are followed, including the scientific criteria that guide the evaluations. Each lARC Monograph is developed by a Working Group of experts who conducted the original research, avoiding real or apparent conflicts of interests. Working Groups typically consist of 20-25 scientists from 8-12 countries, with expertise in cancer epidemiology, experimental carcinogenesis, and related disciplines. The Working Group meets to review and reach consensus on drafts prepared by the experts before the meeting, and to develop and reach consensus on the evaluations. Later, lARC scientists review the text and tables to ensure their scientific accuracy and clarity, and the volume is edited and published. Funds are requested to support two of the three volumes produced each year.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA033193-31
Application #
8327020
Study Section
Special Emphasis Panel (ZCA1-RPRB-7 (J1))
Program Officer
Johnson, Ronald L
Project Start
1985-09-01
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
31
Fiscal Year
2012
Total Cost
$833,601
Indirect Cost
$115,598
Name
International Agency for Research on Cancer
Department
Type
DUNS #
279551881
City
Lyon
State
Country
France
Zip Code
69008
Loomis, Dana; Guyton, Kathryn Z; Grosse, Yann et al. (2016) Carcinogenicity of drinking coffee, mate, and very hot beverages. Lancet Oncol 17:877-8
Cichocki, Joseph A; Guyton, Kathryn Z; Guha, Neela et al. (2016) Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps. J Pharmacol Exp Ther 359:110-23
Guha, Neela; Guyton, Kathryn Z; Loomis, Dana et al. (2016) Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides. Environ Health Perspect 124:1823-1829
Grosse, Yann; Loomis, Dana; Guyton, Kathryn Z et al. (2016) Carcinogenicity of some industrial chemicals. Lancet Oncol 17:419-20
Bouvard, Véronique; Loomis, Dana; Guyton, Kathryn Z et al. (2015) Carcinogenicity of consumption of red and processed meat. Lancet Oncol 16:1599-600
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2014) DIESEL AND GASOLINE ENGINE EXHAUSTS AND SOME NITROARENES. IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS. IARC Monogr Eval Carcinog Risks Hum 105:9-699
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2014) TRICHLOROETHYLENE, TETRACHLOROETHYLENE, AND SOME OTHER CHLORINATED AGENTS. IARC Monogr Eval Carcinog Risks Hum 106:1-512
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2014) MALARIA AND SOME POLYOMAVIRUSES (SV40, BK, JC, AND MERKEL CELL VIRUSES). IARC Monogr Eval Carcinog Risks Hum 104:9-350
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2013) Some chemicals present in industrial and consumer products, food and drinking-water. IARC Monogr Eval Carcinog Risks Hum 101:9-549
IARC Working Group on the Evaluation of Carcinogenic Risk to Humans (2013) Bitumens and bitumen emmissions, and some N- and S-heterocyclic polycyclic aromatic hydrocarbons. IARC Monogr Eval Carcinog Risks Hum 103:9-303

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