This proposed project takes advantage of comprehensive surveillance data on more than 100,000 women offered breast cancer screening through a program with mailed reminders to schedule mammography examinations within a managed care plan (Group Health Cooperative of Puget Sound, GHC). Cancer outcome (mortality, late-stage disease) for the target population are collected through a Surveillance, Epidemiology, and End Results reporting (SEER) registry and are linked to health care process data (service use, mammography assessments). This proposal includes 3 specific aims: 1) To continue breast cancer data system development at GHC to;a) improve data system software, enhance data storage capabilities, and facilitate data retrieval;b) incorporate new data components pertinent to research, such as a targeted survey;and c) maintain and improve data quality assurance, report generation, and data file development;2) To use the data system to conduct 5 initiatives: a) The effect of short-term hormone replacement therapy (HRT) cessation on mammographic density;b) The likelihood of additional imaging (mammography and ultrasound) and the associated costs among women stopping HRT compared to women continuing or never using HRT;C) The factors that explain the reduced sensitivity of mammography among younger women;d) The biologic and other factors that influence the likelihood of late-stage disease;and, e) The effect of screening interval on stage at-diagnosis;and 3) To conduct 5 research projects related to screening mammography: a) The additional effect of mammographic breast density on the 5-year risk of breast cancer;b) Screening sensitivity and specificity by phase of menstrual cycle;c) The association between mammographic findings and cancer among women with """"""""probably benign findings"""""""";d) The effect of computer assisted reading on mammography interpretive performance;and e) Biomarkers associated with nodal metastases at-diagnosis among screened women. By continuing our multi disciplinary collaboration and using carefully designed prospective observational and evaluative studies the investigators will contribute to improvements in breast cancer screening, and the understanding of breast cancer biology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA063731-15S3
Application #
8228665
Study Section
Special Emphasis Panel (ZCA1-SRRB-E (M1))
Program Officer
Marcus, Pamela M
Project Start
1997-06-06
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2011-07-31
Support Year
15
Fiscal Year
2011
Total Cost
$92,750
Indirect Cost
Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101
Wirtz, Heidi S; Calip, Gregory S; Buist, Diana S M et al. (2017) Evidence for Detection Bias by Medication Use in a Cohort Study of Breast Cancer Survivors. Am J Epidemiol 185:661-672
Miglioretti, Diana L; Ichikawa, Laura; Smith, Robert A et al. (2017) Correlation Between Screening Mammography Interpretive Performance on a Test Set and Performance in Clinical Practice. Acad Radiol 24:1256-1264
Buist, Diana S M; Gao, Hongyuan; Anderson, Melissa L et al. (2017) Breast cancer screening outreach effectiveness: Mammogram-specific reminders vs. comprehensive preventive services birthday letters. Prev Med 102:49-58
Brandzel, Susan; Chang, Eva; Tuzzio, Leah et al. (2016) Latina and Black/African American Women's Perspectives on Cancer Screening and Cancer Screening Reminders. J Racial Ethn Health Disparities :
Chubak, Jessica; Bowles, Erin J A; Yu, Onchee et al. (2016) Breast cancer recurrence in relation to antidepressant use. Cancer Causes Control 27:125-36
Nichols, Hazel B; Bowles, Erin J A; Islam, Jessica et al. (2016) Tamoxifen Initiation After Ductal Carcinoma In Situ. Oncologist 21:134-40
Fenton, Joshua J; Onega, Tracy; Zhu, Weiwei et al. (2016) Validation of a Medicare Claims-based Algorithm for Identifying Breast Cancers Detected at Screening Mammography. Med Care 54:e15-22
Bowles, Erin J Aiello; Gao, Hongyuan; Brandzel, Susan et al. (2016) Comparative effectiveness of two outreach strategies for cervical cancer screening. Prev Med 86:19-27
Hullar, Meredith A J; Lancaster, Samuel M; Li, Fei et al. (2015) Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States. Cancer Epidemiol Biomarkers Prev 24:546-54
van Ravesteyn, Nicolien T; Stout, Natasha K; Schechter, Clyde B et al. (2015) Benefits and harms of mammography screening after age 74 years: model estimates of overdiagnosis. J Natl Cancer Inst 107:

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