The AIDS and Cancer Specimen Resource (ACSR) of the National Cancer Institutes (NCI) AIDS Malignancy Program provides HIV/AIDS-related malignant tissues and data to funded/approved cancer researchers to promote a global understanding of the relationships between HIV infection and certain cancers. The Mid Region ACSR (MR-ACSR) consortium, including The Ohio State University (OSU), Emory University, Rush University, University of Tennessee, Memphis, and East African affiliates in Uganda and Kenya, proposes to (specific aim 1) maintain a mid-region ACSR (MR-ACSR) biorepository with affiliates that is compliant with all ACSR rules and recommendations including the NCI Best Practices for Biospecimen Resources and applicable federal regulations and is adequately structured with an Operations Office to perform the principal tasks of collecting, enhancing, storing, and distributing HIV-related, quality assured human tumor tissue with associated clinical, pathological, visual and demographic data to approved investigators. To assure best use of these resources, the MR-ACSR proposes to (specific aim 2) collaborate with ACSR regional biorepositories, NCI AIDS Malignancy Program (AMP) and other NCI AIDS related malignancy and cancer biorepository programs and The Ohio State University Department of Pathology's Human Tissue Resource Network (HTRN) to leverage quality specimen and data availability for translational research in the area of HIV/AIDS-related malignancies. To accomplish the overall objectives of the NCI to promote good health, the MR-ACSR must (specific aim 3) develop original and innovative programs to improve the quality, availability and relevance of biospecimens and associated data using the laboratory facilities and specimen resources of the MR-ACSR consortium including the East African affiliates, The Ohio State University Department of Pathology's HTRN and the Department of Biomedical Informatics caBIG project. MR-ACSR proposes the deployment of a new tissue fixation method to improve preservation of RNA, DNA and tissue proteins for research tissues. Tissue microarray (TMA) construction can be deployed using a """"""""field"""""""" construction format that facilitates diagnostic specimen collection in resource constrained locations. We propose to facilitate the tissue phenotyping of lymphoma (NHL) in sub-Saharan Africa using this TMA format with follow up distant processing and immunohistochemical staining. The MR-ACSR also has a supporting digital microscopy facility for remote visual Internet consultation using digitized images of tissue for data sharing with our collaborators in East Africa, particularly related to diagnostic consultation and review of pathology tissues in cancer clinical treatment trials. Finally, to make the best use of visual data and distant collaboration, the MR-ACSR proposes to work with the developers of caGrid as a clinical resource for digital image data.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA066531-17
Application #
8322124
Study Section
Special Emphasis Panel (ZCA1-SRRB-C (M4))
Program Officer
Liddell Huppi, Rebecca
Project Start
1998-08-12
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
17
Fiscal Year
2012
Total Cost
$692,356
Indirect Cost
$223,148
Name
Ohio State University
Department
Pathology
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Iliyasu, Yawale; Ayers, Leona W; Liman, Almustapha A et al. (2014) EPSTEIN -BARR VIRUS ASSOCIATION WITH MALIGNANT LYMPHOMA SUBGROUPS IN ZARIA, NIGERIA. Niger J Surg Sci 23:6-8
Tumwine, Lynette K; Orem, Jackson; Ayers, Leona W (2014) EBV-Positive Grey Zone Lymphoma in an HIV Infected Man from Kampala, Uganda: Case Report. Int J Med Pharm Case Reports 2:110-116
Joshi, Mandar S; Tong, Liyue; Cook, Angela C et al. (2012) Increased myocardial prevalence of C-reactive protein in human coronary heart disease: direct effects on microvessel density and endothelial cell survival. Cardiovasc Pathol 21:428-35
Abayomi, E A; Somers, A; Grewal, R et al. (2011) Impact of the HIV epidemic and Anti-Retroviral Treatment policy on lymphoma incidence and subtypes seen in the Western Cape of South Africa, 2002-2009: preliminary findings of the Tygerberg Lymphoma Study Group. Transfus Apher Sci 44:161-6
Naresh, Kikkeri N; Raphael, Martine; Ayers, Leona et al. (2011) Lymphomas in sub-Saharan Africa--what can we learn and how can we help in improving diagnosis, managing patients and fostering translational research? Br J Haematol 154:696-703
Ayers, Leona W; Silver, Sylvia; Orenstein, Jan M et al. (2011) The AIDS and Cancer Specimen Resource. Methods Mol Biol 675:193-203
Mwanda, Walter O; Orem, Jackson; Fu, Pingfu et al. (2009) Dose-modified oral chemotherapy in the treatment of AIDS-related non-Hodgkin's lymphoma in East Africa. J Clin Oncol 27:3480-8
Nohle, David G; Hackman, Barbara A; Ayers, Leona W (2005) The tissue micro-array data exchange specification: a web based experience browsing imported data. BMC Med Inform Decis Mak 5:25
Nohle, David G; Ayers, Leona W (2005) The tissue microarray data exchange specification: a document type definition to validate and enhance XML data. BMC Med Inform Decis Mak 5:12
Romer, David J; Yearsley, Kurtis H; Ayers, Leona W (2003) Using a modified standard microscope to generate virtual slides. Anat Rec B New Anat 272:91-7

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