The broad aim of this grant is to expand the material collected by the Australian Breast Cancer Family Study (ABCFS) between 1996 and 2000 on 1,5000 families as part of the CFRBCS, in terms of pathology, biospecimens, clinical data and epidemiology.
The specific aims are for this resource to contribute to the 13 Scientific Modules of this competitive UO1 grant application. This includes a 5 year Systematic Follow-up Study of all 20,000 consenting individuals (8,000 affected) recruited into the CFBRCS, so as to form a prospective cohort study for cancer families. It also includes a study of cases and 750 controls in both Australia and Canada, and replication of positive findings sought by within-family analyses of population-based resources from those two sites, and from Northern California. These two modules are included in this application. It is proposed that an Australian Breast Cancer Family Registry (ABCFR) be created by combining the above material with data collected in 1992- 1995 by the ABCFS on 466 case and 408 control families by the ABCFS using local funds, and by adding a new consortium, the Kathleen Cunningham Foundation Consortium for Research in Familial Breast Cancer (KconFab), also locally funded. Funding is sought for follow-up of an anticipated 400 families, and for testing for mutations in BRCA1 and BRCA2 in 500 KconFab families. As well as being coordinators on the two modules above, the PIs of the ABCFS have a major role on other modules, including the Prognosis and Pathology Characteristics of Heritable Breast Cancer, Estrogen Gene Variants and Breast Cancer, Penetrance and Prevalence of BRCA1/BRCA2 Mutations in the CFRBCS and Identification of Novel Genes Involved in Breast Cancer Susceptibility. Funding is sought for the contribution to these and other modules of data, DNA and administration of questionnaires. This Australian Registry will make a major contribution to the CFRBC's efforts to elucidate the genetic and environmental causes of breast cancer, and translate this into benefits for women at risk of, or affected by, breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA069638-10
Application #
6745085
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (O2))
Program Officer
Seminara, Daniela
Project Start
1995-09-30
Project End
2005-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
10
Fiscal Year
2004
Total Cost
$645,453
Indirect Cost
Name
University of Melbourne
Department
Type
DUNS #
753575117
City
Melbourne
State
Country
Australia
Zip Code
3010
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Dite, Gillian S; MacInnis, Robert J; Bickerstaffe, Adrian et al. (2016) Breast Cancer Risk Prediction Using Clinical Models and 77 Independent Risk-Associated SNPs for Women Aged Under 50 Years: Australian Breast Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 25:359-65
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Rudolph, Anja; Milne, Roger L; Truong, Thérèse et al. (2015) Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors. Int J Cancer 136:E685-96
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Work, M E; John, E M; Andrulis, I L et al. (2014) Reproductive risk factors and oestrogen/progesterone receptor-negative breast cancer in the Breast Cancer Family Registry. Br J Cancer 110:1367-77

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