Abstract

This proposal is for continued funding for the UCSF/Northern California AIDS Malignancies Consortium site. In this proposal for grant renewal the consortium consists of San Francisco General Hospital, University of California San Francisco, Mt. Zion Cancer Center, Kaiser Permanente Medical Center, Pacific Hematology/Oncology Associates, The UC-Davis Medical Center, and The University of Hawaii/AIDS Clinical Research Program for The State of Hawaii. This group of institutions will function as a single participating member of the National Cancer Institute AIDS Malignancies clinical trials consortium for the purpose of enrolling patients with HIV associated malignancies onto clinical trials of novel agents. The six institutions will work together as one unit with a full time data manger for the San Francisco group who will be dedicated to the consortium and will travel to each of the participating sites as necessary for the monitoring of patients on consortium clinical trials. The UC Davis and The University of Hawaii groups will have their own part-time data managers. The Clinicians will interact closely with the San Francisco General Hospital AIDS Immunobiology Laboratory under the direction of Dr. Michael McGrath who will perform necessary laboratory studies on lymphoma specimens and will collect specimens for the NCI-AIDS Malignancies Tissue Repository for which he is the Principal Investigator. In addition, the San Francisco General Hospital General Clinical Research Center (GCRC), which has been actively involved in a variety of clinical trials in HIV disease, will be available for both inpatient and outpatient drug administration and collecting of pharamokenetic specimens as required. This group has a high level of expertise in conducting clinical trials in patients with HIV associated malignancies and consists of clinicians with specialized areas of expertise in management of Kaposi's Sarcoma, non-Hodgkin's lymphoma, and anogenital neoplasias. Clinical trials proposed for consortium studies include a polyamine analog designed to target proliferating macrophages in AIDS-lymphoma, the use of Toremifene with liposomal doxorubicin for treating KS, and a study of an HPV-16 vaccine for treatment of anal neoplasia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA070047-09
Application #
6661958
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (M1))
Program Officer
Bhatia, Kishor
Project Start
1995-09-30
Project End
2006-08-31
Budget Start
2003-08-01
Budget End
2006-08-31
Support Year
9
Fiscal Year
2003
Total Cost
$252,735
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

van der Burg, Sjoerd H; Palefsky, Joel M (2009) Human Immunodeficiency Virus and Human Papilloma Virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful. J Transl Med 7:108
Lechowicz, Maryjo; Dittmer, Dirk P; Lee, Jeannette Y et al. (2009) Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. Clin Infect Dis 49:1946-9
Lin, Lan; Lee, Jeannette Y; Kaplan, Lawrence D et al. (2009) Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood. J Clin Oncol 27:2496-502
Spitzer, Thomas R; Ambinder, Richard F; Lee, Jeannette Y et al. (2008) Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biol Blood Marrow Transplant 14:59-66
Brinker, Brett T; Krown, Susan E; Lee, Jeannette Y et al. (2008) Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer 112:1083-8
Stier, Elizabeth A; Goldstone, Stephen E; Berry, J Michael et al. (2008) Infrared coagulator treatment of high-grade anal dysplasia in HIV-infected individuals: an AIDS malignancy consortium pilot study. J Acquir Immune Defic Syndr 47:56-61
Krown, Susan E; Lee, Jeannette Y; Lin, Lan et al. (2006) Interferon-alpha2b with protease inhibitor-based antiretroviral therapy in patients with AIDS-associated Kaposi sarcoma: an AIDS malignancy consortium phase I trial. J Acquir Immune Defic Syndr 41:149-53
Dezube, Bruce J; Krown, Susan E; Lee, Jeannette Y et al. (2006) Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study. J Clin Oncol 24:1389-94
Palefsky, Joel M; Berry, J Michael; Jay, Naomi et al. (2006) A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals. AIDS 20:1151-5
Kaplan, Lawrence D; Lee, Jeannette Y; Ambinder, Richard F et al. (2005) Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010. Blood 106:1538-43

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