Abstract

A group of experienced investigators in cancer genetics and human cancer virology at the University of Wisconsin have organized a set of projects that would synergize with the MMHCC. These projects include de novo derivations of mouse models for ductal pancreatic carcinoma, cervical carcinoma, uveal melanoma, and Hodgkin's Disease. Further, these investigators propose the further development of extant mouse models for intestinal neoplasia and retinoblastoma leading to validation against the corresponding human disease. More globally, it is proposed to broaden the range of mouse models displaying genetic instability, including deficiencies in double-strand break repair and G-T mismatch repair. These deficiencies will be studied within the set of tissue-specific mouse models for cancer, seeking acceleration of the pathogenetic process within the one-year lifespan of the mouse. Finally, two initiatives of technology development are proposed. One seeks high-resolution MRI imaging at 9.4 Tesla in order to follow directly the regression of mouse tumors whose sizes are often in the mm range. The second seeks a way to develop fluorigenic markers by which to characterize the distinct cell types of the normal intestinal epithelium, document the source of tumors under different genetic and environmental conditions, and cross-reference between mouse and human tumors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01CA084227-01
Application #
6038558
Study Section
Special Emphasis Panel (ZCA1-SRRB-7 (O3))
Program Officer
Marks, Cheryl L
Project Start
1999-09-30
Project End
2004-03-31
Budget Start
1999-09-30
Budget End
2000-03-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Thliveris, Andrew T; Clipson, Linda; Sommer, Lacy L et al. (2012) Regulated Expression of Chromobox Homolog 5 Revealed in Tumors of Apc(Min) (/+) ROSA11 Gene Trap Mice. G3 (Bethesda) 2:569-78
Halberg, Richard B; Waggoner, Jesse; Rasmussen, Kristen et al. (2009) Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res 69:5768-75
Durkee, Benjamin Y; Shinki, Kazuhiko; Newton, Michael A et al. (2009) Longitudinal assessment of colonic tumor fate in mice by computed tomography and optical colonoscopy. Acad Radiol 16:1475-82
Chen, Xiaodi; Halberg, Richard B; Burch, Ryan P et al. (2008) Intestinal adenomagenesis involves core molecular signatures of the epithelial-mesenchymal transition. J Mol Histol 39:283-94
Chen, Xiaodi; Ehrhardt, William M; Halberg, Richard B et al. (2008) Cellular expression patterns of genes upregulated in murine and human colonic neoplasms. J Histochem Cytochem 56:433-41
Kaiser, Sergio; Park, Young-Kyu; Franklin, Jeffrey L et al. (2007) Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 8:R131
Thliveris, Andrew T; Halberg, Richard B; Clipson, Linda et al. (2005) Polyclonality of familial murine adenomas: analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions. Proc Natl Acad Sci U S A 102:6960-5
Pickhardt, Perry J; Halberg, Richard B; Taylor, Andrew J et al. (2005) Microcomputed tomography colonography for polyp detection in an in vivo mouse tumor model. Proc Natl Acad Sci U S A 102:3419-22
Brake, Tiffany; Lambert, Paul F (2005) Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model. Proc Natl Acad Sci U S A 102:2490-5
Haigis, Kevin M; Hoff, Peter D; White, Alanna et al. (2004) Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc Natl Acad Sci U S A 101:9769-73

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