The overarching goal of our proposed infrastructure support project is to promote ongoing data collection using a well-established and vital infrastructure in the New Hampshire Mammography Network (NHMN) (statewide mammography registry) so that we can conduct and promote important research designed to understand and address the problem of breast cancer in NH and beyond. The NHMN, which was implemented in 1996 efficiently obtains demographic, risk factor, and radiologic data on ~ 90% of women having mammography in NH, and then links mammographic encounter information to breast pathology outcomes. The registry has matured to a point where expanded use .ofthis resource for additional research is timely, which will depend on continued support of the NHMN infrastructure. Many studies have been conducted using the NHMN and several more studies have been submitted, which will be described later in this application.
Our Specific Aims are to: 1) Continue and refine current NHMN procedures, including data collection, pathology linkages, feedback reports to mammography facilities and radiologists, and data submissionsto a centralized statistical coordinating center;and 2) Promote the use of NHMN and Consortium data locally, regionally, and regionally. Enrollment in NHMN involves obtaining women's consent to allow access to their medical records and to having themselves or their primary care providers contacted for detailed information about their health and future research. We have a successful track record of conducting research with women and their healthcare providers, including mammographytechnologists, radiologists, pathologists, breast surgeons, and primary health care providers throughout NH. We propose to use these strengths to advance our understanding of breast cancer detection.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project--Cooperative Agreements (U01)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRRB-E (M1))
Program Officer
Marcus, Pamela M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
Family Medicine
Schools of Medicine
United States
Zip Code
Chen, Youdinghuan; Marotti, Jonathan D; Jenson, Erik G et al. (2017) Concordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS). Exp Mol Pathol 103:78-83
Onega, Tracy; Weaver, Donald L; Frederick, Paul D et al. (2017) The diagnostic challenge of low-grade ductal carcinoma in situ. Eur J Cancer 80:39-47
Nutter, Ellen L; Weiss, Julia E; Marotti, Jonathan D et al. (2017) Personal history of proliferative breast disease with atypia and risk of multifocal breast cancer. Cancer :
Miglioretti, Diana L; Ichikawa, Laura; Smith, Robert A et al. (2017) Correlation Between Screening Mammography Interpretive Performance on a Test Set and Performance in Clinical Practice. Acad Radiol 24:1256-1264
Frederick, Paul D; Nelson, Heidi D; Carney, Patricia A et al. (2017) The Influence of Disease Severity of Preceding Clinical Cases on Pathologists' Medical Decision Making. Med Decis Making 37:91-100
Elmore, Joann G; Nelson, Heidi D; Pepe, Margaret S et al. (2016) Variability in Pathologists' Interpretations of Individual Breast Biopsy Slides: A Population Perspective. Ann Intern Med 164:649-55
Goodrich, Martha E; Weiss, Julie; Onega, Tracy et al. (2016) The Role of Preoperative Magnetic Resonance Imaging in the Assessment and Surgical Treatment of Interval and Screen-Detected Breast Cancer in Older Women. Breast J 22:616-622
Fenton, Joshua J; Onega, Tracy; Zhu, Weiwei et al. (2016) Validation of a Medicare Claims-based Algorithm for Identifying Breast Cancers Detected at Screening Mammography. Med Care 54:e15-22
Wolf, Max; Krause, Jens; Carney, Patricia A et al. (2015) Collective intelligence meets medical decision-making: the collective outperforms the best radiologist. PLoS One 10:e0134269
Johnson, Kevin C; Koestler, Devin C; Fleischer, Thomas et al. (2015) DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer. Clin Epigenetics 7:75

Showing the most recent 10 out of 179 publications