The overarching goal of our proposed infrastructure support project is to promote ongoing data collection using a well-established and vital infrastructure in the New Hampshire Mammography Network (NHMN) (statewide mammography registry) so that we can conduct and promote important research designed to understand and address the problem of breast cancer in NH and beyond. The NHMN, which was implemented in 1996 efficiently obtains demographic, risk factor, and radiologic data on ~ 90% of women having mammography in NH, and then links mammographic encounter information to breast pathology outcomes. The registry has matured to a point where expanded use .ofthis resource for additional research is timely, which will depend on continued support of the NHMN infrastructure. Many studies have been conducted using the NHMN and several more studies have been submitted, which will be described later in this application.
Our Specific Aims are to: 1) Continue and refine current NHMN procedures, including data collection, pathology linkages, feedback reports to mammography facilities and radiologists, and data submissionsto a centralized statistical coordinating center;and 2) Promote the use of NHMN and Consortium data locally, regionally, and regionally. Enrollment in NHMN involves obtaining women's consent to allow access to their medical records and to having themselves or their primary care providers contacted for detailed information about their health and future research. We have a successful track record of conducting research with women and their healthcare providers, including mammographytechnologists, radiologists, pathologists, breast surgeons, and primary health care providers throughout NH. We propose to use these strengths to advance our understanding of breast cancer detection.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
3U01CA086082-10S2
Application #
8225832
Study Section
Special Emphasis Panel (ZCA1-SRRB-E (M1))
Program Officer
Marcus, Pamela M
Project Start
2000-05-15
Project End
2011-03-31
Budget Start
2009-08-01
Budget End
2011-03-31
Support Year
10
Fiscal Year
2011
Total Cost
$75,330
Indirect Cost
Name
Dartmouth College
Department
Family Medicine
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Nutter, Ellen L; Weiss, Julia E; Marotti, Jonathan D et al. (2018) Personal history of proliferative breast disease with atypia and risk of multifocal breast cancer. Cancer 124:1350-1357
Chen, Youdinghuan; Marotti, Jonathan D; Jenson, Erik G et al. (2017) Concordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS). Exp Mol Pathol 103:78-83
Geller, Berta M; Nelson, Heidi D; Weaver, Donald L et al. (2017) Characteristics associated with requests by pathologists for second opinions on breast biopsies. J Clin Pathol 70:947-953
Onega, Tracy; Weaver, Donald L; Frederick, Paul D et al. (2017) The diagnostic challenge of low-grade ductal carcinoma in situ. Eur J Cancer 80:39-47
Miglioretti, Diana L; Ichikawa, Laura; Smith, Robert A et al. (2017) Correlation Between Screening Mammography Interpretive Performance on a Test Set and Performance in Clinical Practice. Acad Radiol 24:1256-1264
Frederick, Paul D; Nelson, Heidi D; Carney, Patricia A et al. (2017) The Influence of Disease Severity of Preceding Clinical Cases on Pathologists' Medical Decision Making. Med Decis Making 37:91-100
Fenton, Joshua J; Onega, Tracy; Zhu, Weiwei et al. (2016) Validation of a Medicare Claims-based Algorithm for Identifying Breast Cancers Detected at Screening Mammography. Med Care 54:e15-22
Elmore, Joann G; Nelson, Heidi D; Pepe, Margaret S et al. (2016) Variability in Pathologists' Interpretations of Individual Breast Biopsy Slides: A Population Perspective. Ann Intern Med 164:649-55
Goodrich, Martha E; Weiss, Julie; Onega, Tracy et al. (2016) The Role of Preoperative Magnetic Resonance Imaging in the Assessment and Surgical Treatment of Interval and Screen-Detected Breast Cancer in Older Women. Breast J 22:616-622
Wolf, Max; Krause, Jens; Carney, Patricia A et al. (2015) Collective intelligence meets medical decision-making: the collective outperforms the best radiologist. PLoS One 10:e0134269

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