Over the past several years our multidisciplinary research team has been dedicated to discovering and validating candidate early detection biomarkers for breast and ovary cancers. We are now in an ideal position to lead an EDRN CVC for several reasons: 1. We have lists of promising breast and ovary cancer early detection biomarkers that have been evaluated in Phase 1 to early Phase 3 validation studies that warrant further investigation in Phase 3 studies;2. We have developed considerable expertise in the design, conduct, analysis, and interpretation of cancer biomarker discovery and validation studies;3. Over the course of four work we have developed or gained access to a large number of high quality well-characterized breast and ovary cancer sample repositories that we are willing to share with EDRN;and 4. We have a long history of leading and supporting collaborative projects that have involved shared samples, and we have procedures in place to facilitate the processing and tracking of specimen requests. Herein we propose a new prospective collection of preclinical specimens from breast cancer cases and controls which is unique in that it will include detailed mammography information. We also propose a series of primarily Phase 3 validation studies. For breast cancer we will conduct a Phase 3 study beginning in Year 1 (Study 1) and then plan to design a series of Phase 2 and 3 studies in Years 4-5 (Study 5) as candidates from our work and others in EDRN mature. The primary specific aim of Study 1 is to conduct a second screen of promising candidates identified in a large discovery project using preclinical samples, and to then validate the top candidates in an independent set of preclinical samples from WHI. For ovary cancer we propose a consecutive series of three Phase 3 studies over Years 1-3. Several ovary cancer biomarkers have been validated, but none achieve clinically useful performance on their own. Thus, Study 2 is a Phase 3 validation aimed at validating and refining two- and four-marker algorithms using serial preclinical samples from the PLCO trial. Study 3 will further validate specific screening decision rules in preclinical serial samples from the UKCTOCS trial. Based on Studies 2 and 3, Study 4 will validate ovary cancer markers and screening decision rules in an independent set of WHI serial preclinical samples, a setting in which no ovary cancer screening occurred.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA152637-05
Application #
8688928
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (M1))
Program Officer
Patriotis, Christos F
Project Start
2010-08-16
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
$725,717
Indirect Cost
$300,073
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Buas, Matthew F; Li, Christopher I; Anderson, Garnet L et al. (2018) Recommendation to use exact P-values in biomarker discovery research in place of approximate P-values. Cancer Epidemiol 56:83-89
Rho, Jung-Hyun; Ladd, Jon J; Li, Christopher I et al. (2018) Protein and glycomic plasma markers for early detection of adenoma and colon cancer. Gut 67:473-484
Zhao, Wei; Fitzgibbon, Matthew; Bergan, Lindsay et al. (2017) Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets. Cancer J 23:108-114
Garrison, Carly B; Lastwika, Kristin J; Zhang, Yuzheng et al. (2017) Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections with Obesity. J Proteome Res 16:274-287
Böhm, Jürgen; Pianka, Frank; Stüttgen, Nina et al. (2017) Discovery of novel plasma proteins as biomarkers for the development of incisional hernias after midline incision in patients with colorectal cancer: The ColoCare study. Surgery 161:808-817
Buas, Matthew F; Gu, Haiwei; Djukovic, Danijel et al. (2016) Identification of novel candidate plasma metabolite biomarkers for distinguishing serous ovarian carcinoma and benign serous ovarian tumors. Gynecol Oncol 140:138-44
Urban, Nicole; Hawley, Sarah; Janes, Holly et al. (2015) Identifying post-menopausal women at elevated risk for epithelial ovarian cancer. Gynecol Oncol 139:253-60
Buas, Matthew F; Rho, Jung-hyun; Chai, Xiaoyu et al. (2015) Candidate early detection protein biomarkers for ER+/PR+ invasive ductal breast carcinoma identified using pre-clinical plasma from the WHI observational study. Breast Cancer Res Treat 153:445-54
Wu, Jing; Yin, Haidi; Zhu, Jianhui et al. (2015) Validation of LRG1 as a potential biomarker for detection of epithelial ovarian cancer by a blinded study. PLoS One 10:e0121112
Pepe, Margaret S; Li, Christopher I; Feng, Ziding (2015) Improving the quality of biomarker discovery research: the right samples and enough of them. Cancer Epidemiol Biomarkers Prev 24:944-50

Showing the most recent 10 out of 23 publications