Inflammation-associated cancers of the colon, prostate, and breast have increased dramatically during the past 30 years in Westernized countries resulting in a public health crisis. Concomitantly, health advancements including sterile births and widespread use of antibiotics have led to increasingly hygienic living conditions. We speculate that modernized living practices contribute to gastrointestinal (GI) tract imbalances, which in turn result in inflammatory disorders - such as allergy and asthma - and later in life, inflammation-associated cancers. We have already shown in mouse models that GI tract bacteria modulate growth of cancer in extra-intestinal tissues such as mammary and prostate glands. Here, we aim to understand interactions between GI tract microbiome and breast tumor stromal cells. Partnered with parent U54 grant of Timothy C Wang, MD, this collaborative U01 will build upon our earlier findings relating to breast cancer development. We propose a combination of high-throughput immunology, microbiome analyses and gnotobiotic mouse technologies to elucidate specific mechanisms. We have assembled a world-class team of scientists and physicians uniquely poised to carry out this multi-disciplinary research. We predict that remedies to restore GI tract immune balance will be an effective and practical approach to prevent and treat extra-intestinal malignancies such as breast cancer.

Public Health Relevance

Chronic inflammation increases risk of cancer in humans and in mice. Environmental exposures appear to modulate breast cancer in women but inflammatory mechanisms are not well understood. We have shown in mice that gut bacteria modulate mammary tumors. We propose here to test bowel microbes and inflammatory cells in women and mice with ultimate translational goals to abolish breast cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
4U01CA164337-05
Application #
9130116
Study Section
Special Emphasis Panel (ZCA1-SRLB-C (M1))
Program Officer
Woodhouse, Elizabeth
Project Start
2012-09-26
Project End
2017-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
5
Fiscal Year
2016
Total Cost
$530,389
Indirect Cost
$105,581
Name
Massachusetts Institute of Technology
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02142
Erdman, Susan E; Poutahidis, Theofilos (2017) Gut microbiota modulate host immune cells in cancer development and growth. Free Radic Biol Med 105:28-34
Varian, Bernard J; Poutahidis, Theofilos; DiBenedictis, Brett T et al. (2017) Microbial lysate upregulates host oxytocin. Brain Behav Immun 61:36-49
Poutahidis, Theofilos; Erdman, Susan E (2016) Commensal bacteria modulate the tumor microenvironment. Cancer Lett 380:356-8
Erdman, Susan E; Poutahidis, Theofilos (2015) Gut bacteria and cancer. Biochim Biophys Acta 1856:86-90
Poutahidis, Theofilos; Varian, Bernard J; Levkovich, Tatiana et al. (2015) Dietary microbes modulate transgenerational cancer risk. Cancer Res 75:1197-204
Lakritz, Jessica R; Poutahidis, Theofilos; Mirabal, Sheyla et al. (2015) Gut bacteria require neutrophils to promote mammary tumorigenesis. Oncotarget 6:9387-96
Manzel, Arndt; Muller, Dominik N; Hafler, David A et al. (2014) Role of ""Western diet"" in inflammatory autoimmune diseases. Curr Allergy Asthma Rep 14:404
Lakritz, Jessica R; Poutahidis, Theofilos; Levkovich, Tatiana et al. (2014) Beneficial bacteria stimulate host immune cells to counteract dietary and genetic predisposition to mammary cancer in mice. Int J Cancer 135:529-40
Levkovich, Tatiana; Poutahidis, Theofilos; Cappelle, Kelsey et al. (2014) 'Hygienic' lymphocytes convey increased cancer risk. J Anal Oncol 3:113-121
Erdman, S E; Poutahidis, T (2014) Probiotic 'glow of health': it's more than skin deep. Benef Microbes 5:109-19

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