We propose to enhance the infrastructure of ARIC;the Atherosclerosis Risk in Communities, cohort to yield a new Cancer Epidemiology Cohort that brings novel features to cancer epidemiology research. In 1987, 15,792 participants aged 45-64 years were recruited from Forsyth Co., NC;Jackson, MS;Minneapolis, MN;and Washington Co., MD. 55% are women and 27% are African-American. Participants underwent 4 clinical exams;a 5th is scheduled for 2011. Blood and urine specimens have been banked, medications recorded, and a food frequency questionnaire completed. Participants were interviewed by phone annually and now semi-annually to obtain updated health information. The response at year 21 is 91%. Because ARIC has never been viewed as a Cancer Epidemiology Cohort and infrastructure and cost constraints, only cancer diagnosis has been systematically recorded. By 2006, 3,145 participants were diagnosed with an incident first primary and 376 with a 2nd / 3rd primary. Information, such as stage, grade, and histology, location in organ, laterality, receptor status, treatment, recurrence, and re-treatment, needed to address contemporary questions is not currently available. Tissue needed for molecular/genetic studies has not been collected. Thus, we propose: 1) Starting 2012, to prospectively identify cases from semi-annual phone interviews and collect medical/pathology records pertaining to cancer diagnosis, treatment, recurrence, and retreatment and tissue blocks. 2) To retrospectively collect information characterizing cancer diagnoses and recurrences before 2012 from cancer registries in the 4 ARIC states (consent already obtained) and medical records, and collect tissue blocks. By 2016, we expect 4,900 fully annotated incident cases. We established a Cancer Working Group to develop protocols for adjudicating cancer endpoints and prioritize research using the resource. With enhanced infrastructure, we expect that research questions such as these are addressable uniquely in ARIC: 1) What is the association between timing of the natural history of diabetes using 4 fasting glucose and 2 HbAlc measurements and timing of cancer diagnosis? 2) Using GWAS and sequencing data, is there a set of risk variants shared by major cancers or are variants specific to each site?
Given the wealth of repeated anthropometric, lifestyle, medical data, blood samples and biomarkers;GWAS on all participants;planned DNA sequencing;approved CMS linkage;21-year follow-up;African-American representation;established hospital links;and existing operations protocols, with enhanced infrastructure, ARIC will be a mature Cancer Epidemiology Cohort that brings novel features to cancer research.
|Joshu, Corinne E; Barber, John R; Coresh, Josef et al. (2017) Enhancing the Infrastructure of the Atherosclerosis Risk in Communities (ARIC) Study for Cancer Epidemiology Research: ARIC Cancer. Cancer Epidemiol Biomarkers Prev :|
|Kubota, Yasuhiko; Evenson, Kelly R; Maclehose, Richard F et al. (2017) Physical Activity and Lifetime Risk of Cardiovascular Disease and Cancer. Med Sci Sports Exerc 49:1599-1605|
|Prizment, Anna E; Linabery, Amy M; Lutsey, Pamela L et al. (2016) Circulating Beta-2 Microglobulin and Risk of Cancer: The Atherosclerosis Risk in Communities Study (ARIC). Cancer Epidemiol Biomarkers Prev 25:657-64|
|Coresh, Josef; Platz, Elizabeth A (2016) The George W. Comstock Center for Public Health Research and Prevention: A Century of Collaboration, Innovation, and Translation. Am J Epidemiol 183:362-6|
|Petrick, Jessica L; Foraker, Randi E; Kucharska-Newton, Anna M et al. (2014) Trajectory of overall health from self-report and factors contributing to health declines among cancer survivors. Cancer Causes Control 25:1179-86|
|Han, Xuesong; Stevens, June; Truesdale, Kimberly P et al. (2014) Body mass index at early adulthood, subsequent weight change and cancer incidence and mortality. Int J Cancer 135:2900-9|
|Platz, Elizabeth A (2014) Reflections on success in multidisciplinary, translational science: working together to answer the right questions. Cancer Epidemiol Biomarkers Prev 23:573-4|
|Prizment, Anna E; Yatsuya, Hiroshi; Lutsey, Pamela L et al. (2014) Smoking behavior and lung cancer in a biracial cohort: the Atherosclerosis Risk in Communities study. Am J Prev Med 46:624-32|
|Petrick, Jessica L; Reeve, Bryce B; Kucharska-Newton, Anna M et al. (2014) Functional status declines among cancer survivors: trajectory and contributing factors. J Geriatr Oncol 5:359-67|
|Prizment, Anna E; Folsom, Aaron R; Dreyfus, Jill et al. (2013) Plasma C-reactive protein, genetic risk score, and risk of common cancers in the Atherosclerosis Risk in Communities study. Cancer Causes Control 24:2077-87|