Program Director/Principal Investigator (Bernstam, Elmer Victor) Abstract Genomic analysis of individual patients is now affordable and therapies targeted to specific molecular aberrations are being tested in clinical trials. However, even highly-specialized physicians at leading academic centers are not equipped to apply genomic information available in publically available sources to clinical- decision-making concerning individual patients. Our central hypothesis is that we can develop informatics tools to support personalized cancer treatment as """"""""standard of care"""""""" rather than """"""""one off"""""""" exceptions. We will: 1) implement a bioinformatics pipeline for processing molecular data into actionable profiles, 2) create and maintain a database of therapeutic implications of common genomic aberrations using automated processing of publically-available sources and 3) develop tools to summarize and present patient-specific advice to clinicians. These tools will be based on existing technologies and publicly available data sources. Once tested, we will make these tools available via appropriate open source license. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

Public Health Relevance

Genomic analysis of individual patients is now affordable and therapies targeted to specific molecular aberrations are being tested in clinical trials. In this project, we will develop informatics tools to support personalized cancer treatment as standard of care rather than one off exception.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01CA180964-01
Application #
8607017
Study Section
Special Emphasis Panel (ZCA1-SRLB-4 (O1))
Program Officer
Jessup, John M
Project Start
2013-09-01
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$335,040
Indirect Cost
$77,740
Name
University of Texas Health Science Center Houston
Department
Type
Schools of Allied Health Profes
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
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Meric-Bernstam, Funda; Johnson, Amber; Holla, Vijaykumar et al. (2015) A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst 107:
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