HIV-infected injection drug users (IDUs) represent a marginalized population with substantial disparities in health care access and outcomes. Since 1988, the AIDS Linked to the Intravenous Experience (ALIVE) study has followed disadvantaged, predominantly African American HIV-infected and at-risk IDUs in a community-based observational cohort, providing important evidence on the natural and treated course of HIV among IDUs. We have characterized the rates and risk factors for incident HIV infection and for progression to AIDS or death, described patterns of risk behavior, and determined barriers to optimal HIV care. Since availability of effective antiretroviral therapy (ART), optimal HIV care is now achieved by early HIV testing;prompt linkage to HIV care, timely initiation of ART, high adherence, retention in care, and prolonged virological suppression. Drug use may have detrimental effects at each stage of this HIV Care Continuum. Proposed is a multidisciplinary research agenda with the primary objective to continue the epidemiological, pathogenesis, behavioral, and clinical characterization of the evolving HIV epidemic among IDUs as they age and drug use patterns change. While the cohort has and continues to be a platform for an array of studies critical to addressing critical on HIV and drug use, this proposal emphasizes examination of IDUs'navigation of the HIV Care Continuum.
We aim to characterize the dynamic nature of the Care Continuum and to identify the key determinants of successful navigation and the consequences of stagnation. Successful navigation entails consistent engagement in care with prompt ART initiation and prolonged viral suppression. In contrast, we introduce the concept of stagnation, incorporating navigation patterns involving a failure to progress and delayed or relapsing transitions through the Continuum. We will describe longitudinal navigation patterns, characterize the time required to transition through stages, and identify sociodemographic, behavioral, provider and neighborhood-level determinants of the primary navigation patterns. We hypothesize that less successful navigation (stagnation) in the Care Continuum will have serious clinical consequences, increasing the risk for both AIDS or non-AIDS events as well as death. The key impact of this aim is to illuminate mechanisms, identify modifiable risk factors, and provide novel insight to inform efficient and targeted intervention development to mitigate the consequences of less effective HIV care among IDUs. To achieve these aims, we continue biannual visits with interview, exam, and biospecimen collection supplemented by medical record review and registry linkage. ALIVE represents the minority, socially-marginalized population at highest risk for HIV progression and limited access to care in Baltimore and nationally. The ALIVE study remains well- positioned to address these emerging issues confronting aging HIV-infected IDUs, namely characterizing long- term outcomes and enhancing HIV care through improving navigation of the HIV Care Continuum.

Public Health Relevance

This proposal supports continuation of the AIDS Linked to the Intravenous Experience (ALIVE) study which has followed disadvantaged, predominantly African American HIV-infected and at-risk injection drug users (IDUs) in a community-based cohort since 1988. ALIVE provides a platform for longitudinally measuring risk behavior, treatment outcomes, disease incidence and prevalence, and cause-specific mortality among aging HIV-infected IDUs while also supporting independently-funded investigations of HIV and drug use. Focusing on how IDUs'navigate the HIV Care Continuum, we aim to understand mechanisms, identify modifiable risk factors, and inform intervention development to improve the effectiveness of HIV care among IDUs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01DA036297-01
Application #
8597089
Study Section
Special Emphasis Panel (ZDA1-NXR-B (15))
Program Officer
Lambert, Elizabeth
Project Start
2014-01-01
Project End
2018-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
1
Fiscal Year
2014
Total Cost
$1,797,375
Indirect Cost
$634,772
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Drummond, M Bradley; Lambert, Allison A; Hussien, Amira F et al. (2017) HIV Infection Is Independently Associated with Increased CT Scan Lung Density. Acad Radiol 24:137-145
Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390
Piggott, Damani A; Muzaale, Abimereki D; Varadhan, Ravi et al. (2017) Frailty and Cause-Specific Hospitalization Among Persons Aging With HIV Infection and Injection Drug Use. J Gerontol A Biol Sci Med Sci 72:389-394
Veenhuis, Rebecca T; Astemborski, Jacquie; Chattergoon, Michael A et al. (2017) Systemic Elevation of Proinflammatory Interleukin 18 in HIV/HCV Coinfection versus HIV or HCV Monoinfection. Clin Infect Dis 64:589-596
Kirk, Gregory D; Dandorf, Stewart; Li, Huifen et al. (2017) Differential Relationships among Circulating Inflammatory and Immune Activation Biomediators and Impact of Aging and Human Immunodeficiency Virus Infection in a Cohort of Injection Drug Users. Front Immunol 8:1343
Vergara, C; Thio, C; Latanich, R et al. (2017) Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections. Genes Immun 18:82-87
Quinn, Jeffrey; Astemborski, Jacquie; Mehta, Shruti H et al. (2017) HIV/HCV Co-infection, Liver Disease Progression, and Age-Related IGF-1 Decline. Pathog Immun 2:50-59
Popescu, Iulia; Drummond, M Bradley; Gama, Lucio et al. (2016) HIV Suppression Restores the Lung Mucosal CD4+ T-Cell Viral Immune Response and Resolves CD8+ T-Cell Alveolitis in Patients at Risk for HIV-Associated Chronic Obstructive Pulmonary Disease. J Infect Dis 214:1520-1530
Walker-Sperling, Victoria E; Merlo, Christian A; Buckheit 3rd, Robert W et al. (2016) Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages. AIDS Res Hum Retroviruses 32:1097-1099
Lambert, Allison A; Drummond, M Bradley; Kisalu, Annamarie et al. (2016) Implementation of a COPD Screening Questionnaire in an Outpatient HIV Clinic. COPD 13:767-772

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