Hearing loss is the most common sensory disorder in the US, afflicting over 36 million people; thus, identification of modifiable risk factors is a vital public health issue. Strikingly, there are only limited prospective data on common and potentially modifiable risk factors for this highly prevalent, disabling condition. In addition to noise, factors potentially associated with risk of hearing loss include analgesics, vitamins, alcohol, menopausal status and postmenopausal hormone use. Aspirin, acetaminophen and ibuprofen are the three most commonly used drugs in the U.S. The ototoxic effects of high dose salicylates are well-known. Our preliminary studies in men found an increased risk of hearing loss with regular moderate use of aspirin, NSAIDs, and acetaminophen;however, this has not been prospectively studied in women. Vitamins, such as folate, A, C, D, and E, may play important roles in maintenance of hearing. Alcohol intake may have a variable impact on hearing, depending on the level of use. Additionally, estrogen may play a role in hearing function, thus menopausal status and postmenopausal hormone use may have important implications for hearing loss. We will examine these issues prospectively in large ongoing cohort studies involving over 150,000 women (Nurses'Health Studies I and II). To identify factors that can be modified at an early stage to conserve hearing, will examine audiometrically measured change in hearing sensitivity over 3 years in a subset of 3000 women in NHS II with either no or mild hearing loss. The secondary outcome will be selfreported professionally diagnosed hearing loss in the entire study population. We expect more than 5000 incident cases in each female cohort to be identified and confirmed by a supplementary questionnaire. We will use a multidisciplinary approach to examine the association between these common factors and the risk of hearing loss.

Public Health Relevance

Hearing loss is a very common sensory disorder in the US, afflicting over 36 million people; thus, identification of factors that can be modified to reduce the likelihood of developing hearing loss is a vital public health issue. Using several ongoing large prospective studies involving more than 150,000 women, we will examine whether common pain relievers, vitamins, alcohol, menopausal status and postmenopausal hormone use are associated with the risk of developing hearing loss. We will also perform hearing tests in 3000 women to examine whether these factors influence change in hearing sensitivity.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DC010811-03
Application #
8495109
Study Section
Neurological, Aging and Musculoskeletal Epidemiology (NAME)
Program Officer
Hoffman, Howard J
Project Start
2011-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$459,952
Indirect Cost
$158,920
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Lin, Brian M; Curhan, Sharon G; Wang, Molin et al. (2017) Prospective Study of Gastroesophageal Reflux, Use of Proton Pump Inhibitors and H2-Receptor Antagonists, and Risk of Hearing Loss. Ear Hear 38:21-27
Lin, Brian M; Li, Wen-Qing; Curhan, Sharon G et al. (2017) Skin Pigmentation and Risk of Hearing Loss in Women. Am J Epidemiol 186:1-10
Lin, Brian M; Curhan, Sharon G; Wang, Molin et al. (2017) Duration of Analgesic Use and Risk of Hearing Loss in Women. Am J Epidemiol 185:40-47
Curhan, Sharon G; Eliassen, A Heather; Eavey, Roland D et al. (2017) Menopause and postmenopausal hormone therapy and risk of hearing loss. Menopause 24:1049-1056
Lin, Brian M; Hu, Frank B; Curhan, Gary C (2017) Association Between Benzodiazepine Receptor Agonists and Snoring Among Women in the Nurses' Health Study. JAMA Otolaryngol Head Neck Surg 143:162-167
Lin, Brian M; Curhan, Sharon G; Wang, Molin et al. (2016) Hypertension, Diuretic Use, and Risk of Hearing Loss. Am J Med 129:416-22
Curhan, Sharon G; Eavey, Roland; Wang, Molin et al. (2015) Prospective study of alcohol consumption and self-reported hearing loss in women. Alcohol 49:71-7
Curhan, Sharon G; Stankovic, Konstantina M; Eavey, Roland D et al. (2015) Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. Am J Clin Nutr 102:1167-75
Curhan, Sharon G; Eavey, Roland D; Wang, Molin et al. (2014) Fish and fatty acid consumption and the risk of hearing loss in women. Am J Clin Nutr 100:1371-7
Plotkin, Scott R; Ardern-Holmes, Simone L; Barker 2nd, Fred G et al. (2013) Hearing and facial function outcomes for neurofibromatosis 2 clinical trials. Neurology 81:S25-32

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