The purpose of this project is to identify modifiable maternal exposures in early pregnancy that may increase the risk for having a pregnancy affected by certain major, structural birth defects. Grantees will use data from existing birth defects surveillance systems to identify children with the 17 birth defects categories. Mothers of these case infants and mothers of randomly selected live born control infants will be contacted and invited to participate in a maternal interview. The interview will focus on the key areas of: () diabetes, obesity, and physical activity;(2) other chronic maternal medical conditions;(3) infertility;and (4) medication use;in addition to other exposures with promising prevention potential such as genitourinary infections, fever, and maternal occupation. Kits will be mailed to participating families to collect saliva samples and provisions will be made for the collection of residual newborn bloodspots, enhancing the potential for gene-environment interaction studies.

Public Health Relevance

Nationwide, congenital malformations are the leading cause of death among infants in the first year of life, about 4% of all live born infants have a major birth defect. Not all children die, many who live have resulting morbidity and disability, high health care costs and families may face large burdens both personal and financial. Over 60% of birth defects are of unknown origin, recent developments, such as folic acid, hold out the promise of preventing birth defects. The BD-Steps will focus on modifiable factors in an effort to prevent the occurrence of birth defects.

Agency
National Institute of Health (NIH)
Institute
Centers for Disease Control and Prevention (NCBDD)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DD001032-02
Application #
8722857
Study Section
Special Emphasis Panel (ZDD1-EEO (01))
Project Start
2013-09-01
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
2
Fiscal Year
2014
Total Cost
$765,000
Indirect Cost
$115,201
Name
Center of Environmental Health
Department
Type
DUNS #
620832753
City
Menands
State
NY
Country
United States
Zip Code
12204