Birth defects are the leading cause of infant mortality in the US. Birth defects also have enormous associated emotional and fiscal costs. The California Center's research efforts, both independently and in collaboration with other Centers for Birth Defects Research and Prevention (CBDRP) contributing to the National Birth Defects Prevention Study (NBDPS), have been at the forefront of public health birth defects research. With this new funding opportunity, our Center will further enhance scientific understanding of the potential causes of specific birth defects, which will undoubtedly have important implications for risk assessment and prevention of common, costly, and deadly malformations. In this application, we propose the following aims:
Aim 1. Enhance the epidemiologic public health research capacity of the Centers for Birth Defects and Research and Prevention by actively participating in the Birth Defects Study to Evaluate Pregnancy Exposures (BD-STEPS) and Aim 2. Utilize data from BD-STEPS as well as NBDPS for collaborative and local studies that will identify potential modifiable risk factors for selected birth defects to reduce the public heath burden of birth defects in the US. The California Center is well-equipped to contribute to BD-STEPS - it is a world leader in birth defects epidemiology and highly experienced in the development, data collection, and dissemination of information from population-based studies of birth defects, exemplified by its performance within the CBDRP and its highly innovative research portfolio. Our Center has extensive experience conducting research related to the BD- STEPS areas of focus, which include maternal chronic medical conditions, diabetes, obesity, physical activity, infertility and medication use. We have proposed several analytic inquiries, complemented by the use of additional innovative datasets and analytic approaches, which will enable us to collaboratively continue elucidating the contribution of these and other modifiable risk factors to birth defects.
The proposed research will improve our understanding of the causes of birth defects and ways to prevent them. Its findings will contribute to the development of effective interventions or prevention messages, so that these common, costly outcomes can be prevented.
| Carmichael, Suzan L; Ma, Chen; Van Zutphen, Alissa R et al. (2018) Women's periconceptional diet and risk of biliary atresia in offspring. Birth Defects Res 110:994-1000 |
| Helle, Emmi I T; Biegley, Preston; Knowles, Joshua W et al. (2018) First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring. J Pediatr 195:275-278 |
| Weber, Kari A; Yang, Wei; Carmichael, Suzan L et al. (2018) An application of data mining to identify potential risk factors for anophthalmia and microphthalmia. Paediatr Perinat Epidemiol 32:545-555 |
| Francis, Stephen S; Wiemels, Joseph L; Yang, Wei et al. (2018) Herpesvirus Infection in Infants with Gastroschisis. Epidemiology 29:571-573 |
| Bruckner, Tim A; Karasek, Deborah; Yang, Wei et al. (2017) Cohort Variation in Selection During Pregnancy and Risk of Selected Birth Defects Among Males. Epidemiology 28:580-586 |
| Kaufeld, Kimberly A; Fuentes, Montse; Reich, Brian J et al. (2017) A Multivariate Dynamic Spatial Factor Model for Speciated Pollutants and Adverse Birth Outcomes. Int J Environ Res Public Health 14: |
| Carmichael, Suzan L; Yang, Wei; Roberts, Eric et al. (2016) Residential agricultural pesticide exposures and risks of selected birth defects among offspring in the San Joaquin Valley of California. Birth Defects Res A Clin Mol Teratol 106:27-35 |
| Wadhwa, Elizabeth L; Ma, Chen; Shaw, Gary M et al. (2016) Gastroschisis and maternal intake of phytoestrogens. Am J Med Genet A 170:2078-82 |
| Hagen, Erin M; Sicko, Robert J; Kay, Denise M et al. (2016) Copy-number variant analysis of classic heterotaxy highlights the importance of body patterning pathways. Hum Genet 135:1355-1364 |
| Carmichael, Suzan L; Yang, Wei; Gilboa, Suzanne et al. (2016) Elevated body mass index and decreased diet quality among women and risk of birth defects in their offspring. Birth Defects Res A Clin Mol Teratol 106:164-71 |
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